| Title: |
Determinants of Anti-S Immune Response at 9 Months after COVID-19 Vaccination in a Multicentric European Cohort of Healthcare Workers-ORCHESTRA Project. |
| Authors: |
Collatuzzo G; Lodi V; Feola D; De Palma G; Sansone E; Sala E; Janke C; Castelletti N; Porru S; Spiteri G; Monaco MGL; Larese Filon F; Negro C; Cegolon L; Beresova J; Fabianova E; Carrasco-Ribelles LA; Toràn-Monserrat P; Rodriguez-Suarez MM; Fernandez-Tardon G; Asafo SS; Ditano G; Abedini M; Boffetta P. |
| Contributors: |
Collatuzzo, G; Lodi, V; Feola, D; De Palma, G; Sansone, E; Sala, E; Janke, C; Castelletti, N; Porru, S; Spiteri, G; Monaco, Mgl; Larese Filon, F; Negro, C; Cegolon, L; Beresova, J; Fabianova, E; Carrasco-Ribelles, La; Toràn-Monserrat, P; Rodriguez-Suarez, Mm; Fernandez-Tardon, G; Asafo, S; Ditano, G; Abedini, M; Boffetta, P. |
| Publication Year: |
2022 |
| Collection: |
Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| Subject Terms: |
COVID-19; antibody level; immunization; serology; temporal trend; vaccine |
| Description: |
Background: The persistence of antibody levels after COVID-19 vaccination has public health relevance. We analyzed the determinants of quantitative serology at 9 months after vaccination in a multicenter cohort. Methods: We analyzed data on anti-SARS-CoV-2 spike antibody levels at 9 months from the first dose of vaccinated HCW from eight centers in Italy, Germany, Spain, Romania and Slovakia. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of one standard deviation of log antibody level and the corresponding 95% confidence interval (CI), and combined them in random-effects meta-analyses. Finally, we conducted a trend analysis of 1 to 7 months' serology within one cohort. Results: We included 20,216 HCW with up to two vaccine doses and showed that high antibody levels were associated with female sex (p = 0.01), age (RR = 0.87, 95% CI = 0.86-0.88 per 10-year increase), 10-day increase in time since last vaccine (RR = 0.97, 95% CI 0.97-0.98), previous infection (3.03, 95% CI = 2.92-3.13), two vaccine doses (RR = 1.22, 95% CI = 1.09-1.36), use of Spikevax (OR = 1.51, 95% CI = 1.39-1.64), Vaxzevria (OR = 0.57, 95% CI = 0.44-0.73) or heterologous vaccination (OR = 1.33, 95% CI = 1.12-1.57), compared to Comirnaty. The trend in the Bologna cohort, based on 3979 measurements, showed a decrease in mean standardized antibody level from 8.17 to 7.06 (1-7 months, p for trend 0.005). Conclusions: Our findings corroborate current knowledge on the determinants of COVID-19 vaccine-induced immunity and declining trend with |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36560660; info:eu-repo/semantics/altIdentifier/wos/WOS:000904508800001; volume:14; issue:12; firstpage:"-"; lastpage:"-"; numberofpages:13; journal:VIRUSES; https://hdl.handle.net/11368/3037941; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781450/ |
| DOI: |
10.3390/v14122657 |
| Availability: |
https://hdl.handle.net/11368/3037941; https://doi.org/10.3390/v14122657; https://www.mdpi.com/1999-4915/14/12/2657; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781450/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.B995DCFE |
| Database: |
BASE |