| Title: |
Diagnostic and epidemiological landscape of anaerobic bacteria in Europe, 2020-2023 (ANAEuROBE) |
| Authors: |
Boattini, Matteo; Bianco, Gabriele; Bastos, Paulo; Mavromanolaki, Viktoria Eirini; Maraki, Sofia; Spiliopoulou, Anastasia; Kakouris, Vasileios; Kalchev, Yordan; Budimir, Ana; Bedenic, Branka; Rubic, Zana; Licker, Monica; Musuroi, Corina; Juhasz, Emese; Kristof, Katalin; Pirs, Mateja; Velimirovic, Ivana; Berktold, Michael; Liptakova, Adriana; Krajcikova, Adriana; Drevinek, Pavel; Gryndlerova, Anezka; Brzychczy-Wloch, Monika; Olechowska-Jarzab, Aldona; Bielec, Filip; Brauncajs, Malgorzata; Podsiadly, Edyta; Nurzynska, Grazyna; Zalas-Wiecek, Patrycja; Riesbeck, Kristian; Andersson, Hanna-Sofia; Tonjum, Tone; Berild, Johan Christian; Leegaard, Truls Michael; Rasmussen, Asger Nellemann; Schonning, Kristian; Glockner, Stefan; Rodel, Jurgen; Badr, Mohamed Tarek; Hacker, Georg Alexander; Stark, Denise; Hamprecht, Axel; Dudakova, Anna; Jantsch, Jonathan; Mancini, Stefano; Quiblier, Chantal; Jacot, Damien; Greub, Gilbert; Ferniani, Tiziano; Ambretti, Simone; Calvo, Maddalena; Stefani, Stefania; Schade, Rogier; Yusuf, Erlangga; van Koeveringe, Stefanie; Vandamme, Sarah; Verroken, Alexia; Rodriguez-Villalobos, Hector; Duigou, Francois; Corvec, Stephane; Floch, Pauline; Massip, Clemence; Chainier, Delphine; Barraud, Olivier; Louissaint, Marie-Bossuete; Mizrahi, Assaf; Ali, Saied; Doyle, Maeve; Egan, Clarice; McNicholas, Sinead; Colomina-Rodriguez, Javier; Torres, Ignacio; Luengo, Raul Gilarranz; Escartin, Maria Nieves Larrosa; Perez, Maria Belen Vinado; Halperin, Ana Veronica; Garcia, Sergio Fuente; Canton, Rafael; Seruca, Miguel; Mendes, Vasco Santos; Carvalho, Dinah; Cavallo, Rossana; Cristino, Jose Melo; Costa, Cristina |
| Source: |
0924-8579 ; International journal of antimicrobial agents |
| Publication Year: |
2025 |
| Collection: |
IRUA - Institutional Repository van de Universiteit Antwerpen |
| Subject Terms: |
Biology; Human medicine |
| Description: |
Introduction: Despite being implicated in a wide spectrum of community-and healthcare-acquired infections, anaerobes have not yet been incorporated into systematic surveillance programs in Europe. Methods: We conducted a multicentre retrospective observational study analysing all anaerobic strains isolated from blood cultures in 44 European Hospital Centres over a 4-y period (2020-2023). Diagnostic approach, epidemiology, and antimicrobial susceptibility according to EUCAST v. 15.0 were investigated. Results: Our study included 14,527 anaerobes, most of which were Gram-positive (45%) or Gram-negative (40%) bacilli. MALDI-TOF coupled to mass spectrometry was the most widely used tool for species identification (98%). Antimicrobial susceptibility testing was performed in the vast majority of centres, using mostly gradient diffusion strip (77%) and disk diffusion (45%) methods according to EUCAST guidelines. The most prevalent species were Cutibacterium acnes (18.7%), Bacteroides fragilis (16.3%), Clostridium perfringens (5.3%), Bacteroides thetaiotaomicron (4.2%), Fusobacterium nucleatum (3.5%), and Parvimonas micra (3.4%). C. acnes showed high resistance to benzylpenicillin (18%), clindamycin (39%), and imipenem (19% and 13% by MIC methods and disk diffusion, respectively). B. fragilis showed high resistance to amoxicillin/clavulanate (24%), piperacillin/tazobactam (22% and 14% by MIC methods and disk diffusion, respectively), clindamycin (22% by both MIC methods and disk diffusion), meropenem (13%), and metronidazole (10%, only by disk diffusion). A similar resistance pattern was observed in B. thetaiotaomicron, Bacteroides ovatus, and Parabacteroides distasonis. C. perfringens showed high resistance to clindamycin (69% and 45% by MIC methods and disk diffusion, respectively), while benzylpenicillin and metronidazole maintained over 90% activity. F. nucleatum showed high resistance to benzylpenicillin (11%), while Fusobacterium necrophorum showed alarming rates of resistance to clindamycin (12%), ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/isi/001492215800001 |
| Availability: |
https://hdl.handle.net/10067/2144100151162165141; https://repository.uantwerpen.be/docstore/d:irua:29025 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.B9F76769 |
| Database: |
BASE |