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Treatment efficacy of ribociclib or palbociclib plus letrozole in hormone receptor-positive/HER2-negative metastatic breast cancer

Title: Treatment efficacy of ribociclib or palbociclib plus letrozole in hormone receptor-positive/HER2-negative metastatic breast cancer
Authors: Ozkanli, Gulhan; Duman, Berna Bozkurt; Aydin, Dincer; Dulgar, Ozgecan; Er, Muhammed Muhiddin; Teker, Fatih; Yavuzsen, Tugba; Aykan, Musa Baris; Inal, Ali; Iriagac, Yakup; Kalkan, Nurhan Onal; Keser, Murat; Kut, Engin; Bilgin, Burak; Karaoglanoglu, Muge; Ozdemir, Ozlem; Turhal, Nazim Serdar; Karadurmus, Nuri; Yalcin, Bulent; Sendur, Mehmet Ali Nahit; Çakan Demirel, Burçin; Paydas, Semra; Kahraman, Seda; Erul, Enes; Seyyar, Mustafa; Gümüşay, Özge; Bayram, Ertuğrul; Acar, Ömer; Aksoy, Sercan; Baytemur, Naziyet Kose; Sahin, Elif; Cabuk, Devrim; Basaran, Gül; Guven, Deniz Can; Erdogan, Atike Pinar; Demirci, Umut; Yasar, Alper; Bayoglu, Ibrahim Vedat; Hizal, Mutlu; Gulbagci, Burcu; Paksoy, Nail; Yilmaz, Funda; Dogan, Ozlem; Orhan, Sibel Oyucu; Kayikcioglu, Erkan; Aytac, Ali; Unal, Olcun Umit; Demir, Hacer; Erol, Cihan; Selcukbiricik, Fatih; Sakalar, Teoman; Sunar, Veli; Keskinkilic, Merve; Mocan, Eda Eylemer; Aydin, Esra; Yucel, Hakan; Isik, Deniz; Eren, Onder; Uluc, Basak Oyan; Ozcelik, Melike; Hacibekiroglu, Ilhan; Aydiner, Adnan; Oksuzoglu, Berna; Cilbir, Ebru; Cubukcu, Erdem; Cetin, Bulent; Oktay, Esin; Okutur, Sadi Kerem; Yildirim, Nilgun; Alkan, Ali; Aksoy, Asude; Karakas, Yusuf; Yaren, Arzu
Publisher Information: Future Medicine Ltd
Publication Year: 2023
Collection: Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi
Subject Terms: CDK 4; 6 inhibitors; HER2-negative metastatic breast cancer; HR-positive; letrozole
Description: Article; Early Access ; Background: Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase inhibitors as the first-line standard-of-care for patients with hormone receptor-positive, HER2-negative metastatic breast cancer. Methods: The authors report retrospective real-life data for 600 patients with estrogen receptor- and/or progesterone receptor-positive and HER2-negative metastatic breast cancer who were treated with ribociclib and palbociclib in combination with letrozole. Results ; conclusion: The results demonstrated that the combination of palbociclib or ribociclib with letrozole has similar progression-free survival and overall survival benefit in real life for the patient group with similar clinical features. Specifically, endocrine sensitivity may be a factor to be considered in the treatment preference.
Document Type: article in journal/newspaper
Language: English
Relation: Future Oncology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/51149; WOS:000991646700001
DOI: 10.2217/fon-2022-1287
Availability: https://hdl.handle.net/11499/51149; https://doi.org/10.2217/fon-2022-1287
Rights: none
Accession Number: edsbas.BA24BFA2
Database: BASE