| Title: |
Bisphenol S alters the steroidome in the preovulatory follicle, oviduct fluid and plasma in ewes with contrasted metabolic status |
| Authors: |
Téteau, Ophélie; Liere, Philippe; Pianos, Antoine; Desmarchais, Alice; Lasserre, Olivier; Papillier, Pascal; Vignault, Claire; Lebachelier de La Riviere, Marie-Emilie; Maillard, Virginie; Binet, A.; Uzbekova, Svetlana; Saint-Dizier, Marie; Elis, Sébastien |
| Contributors: |
Physiologie de la reproduction et des comportements Nouzilly (PRC); Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT); NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Maladies et hormones du système nerveux (DHNS); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO); Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Centre Hospitalier Régional Universitaire de Tours (CHRU Bretonneau); ANR-18-CE34-0011,MAMBO,Impact du métabolisme sur les effets ovariens du bisphenol S(2018) |
| Source: |
ISSN: 1664-2392 ; Frontiers in Endocrinology ; https://hal.inrae.fr/hal-03681100 ; Frontiers in Endocrinology, 2022, 13, pp.1-18. ⟨10.3389/fendo.2022.892213⟩. |
| Publisher Information: |
CCSD; Frontiers |
| Publication Year: |
2022 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
endocrine disruptors; bisphenol S; metabolic status; ewe; steroidome; [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology; [SDE]Environmental Sciences; [SDV]Life Sciences [q-bio]; [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism; [SDV.SA]Life Sciences [q-bio]/Agricultural sciences; [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain |
| Description: |
International audience ; Bisphenol A (BPA), a plasticizer and endocrine disruptor, has been substituted by bisphenol S (BPS), a structural analogue that had already shown adverse effects on granulosa cell steroidogenesis. The objective of this study was to assess the effect of chronic exposure to BPS, a possible endocrine disruptor, on steroid hormones in the ovary, oviduct and plasma using the ewe as a model. Given the interaction between steroidogenesis and the metabolic status, the BPS effect was tested according to two diet groups. Eighty adult ewes were allotted to restricted (R) and well-fed (WF) groups, that were further subdivided into two subgroups. Ewes were exposed to 50 µg BPS/kg/day in their diet (R50 and WF50 groups) or were unexposed controls (R0 and WF0 groups). After at least 3 months of BPS exposure, preovulatory follicular fluid, oviduct fluid and plasma were collected and steroid hormones were analyzed by gas chromatography coupled with tandem mass spectrometry (GC-MS/MS). A deleterious effect of restricted diet on the volume of oviduct fluid and numbers of pre-ovulatory follicles was observed. Exposure to BPS impaired estradiol concentrations in both follicular and oviduct fluids of well-fed ewes and progesterone, estradiol and estrone concentrations in plasma of restricted ewes. In addition, a significant interaction between metabolic status and BPS exposure was observed for seven steroids, including estradiol. In conclusion, BPS acts in ewes as an endocrine disruptor with differential actions according to metabolic status. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35685208; PUBMED: 35685208; PUBMEDCENTRAL: PMC9172638; WOS: 000807705900001 |
| DOI: |
10.3389/fendo.2022.892213 |
| Availability: |
https://hal.inrae.fr/hal-03681100; https://hal.inrae.fr/hal-03681100v1/document; https://hal.inrae.fr/hal-03681100v1/file/2022_Teteau%20et%20al.%202022%20Frontiers%20steroidomic.pdf; https://doi.org/10.3389/fendo.2022.892213 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.BA28FBD8 |
| Database: |
BASE |