| Title: |
Apparent sterilizing immunity in BCG-immunized mice challenged with an ultra-low dose of Mycobacterium tuberculosis |
| Authors: |
Plumlee, Courtney R; Duffy, Fergal J; Gern, Benjamin H; Delahaye, Jared L; Cohen, Sara B; Rustad, Tige R; Aitchison, John D; Sherman, David R; Zak, Daniel E; Gerner, Michael Y; Urdahl, Kevin B |
| Source: |
The Journal of Immunology ; volume 204, issue 1_Supplement, page 231.25-231.25 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2020 |
| Description: |
Tuberculosis (TB) is a highly heterogeneous disease that develops in a subset of individuals infected with aerosolized Mycobacterium tuberculosis (Mtb). To improve upon the standard experimental mouse model, we infected mice with an ultra-low Mtb dose (ULD), consisting of 1-3 founding bacteria, which reflects the physiologic inoculum of humans. These mice exhibited a broad range of outcomes, with bacterial burdens ranging from |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.204.supp.231.25 |
| Availability: |
https://doi.org/10.4049/jimmunol.204.supp.231.25; https://academic.oup.com/jimmunol/article/204/1_Supplement/231.25/7950162 |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.BA967E7E |
| Database: |
BASE |