| Title: |
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study |
| Authors: |
Gharibzadeh, S; Routen, A; Razieh, C; Zaccardi, F; Lawson, C; Gillies, C; Heller, S; Davies, M; Atkins, H; Bain, SC; Lone, NL; Poinasamy, K; Peto, T; Robertson, E; Young, B; Johnston, D; Quint, J; Valabhji, J; Ismail, K; Marks, M; Horsley, A; Docherty, A; Harrison, E; Chalmers, J; Ho, LP; Raman, B; Brightling, C; Elneima, O; Evans, R; Greening, N; Harris, VC; Houchen-Wolloff, L; Sereno, M; Shikotra, A; Singapuri, A; Wain, L; Langenberg, C; Dennis, J; Petrie, J; Sattar, N; Leavy, O; Richardson, M; Saunders, RM; McArdle, A; McASuley, H; Yates, T; Khunti, K |
| Publisher Information: |
Elsevier |
| Publication Year: |
2024 |
| Collection: |
Queen Mary University of London: Queen Mary Research Online (QMRO) |
| Description: |
Background: People with diabetes are at increased risk of hospitalisation, morbidity, and mortality following SARS-CoV-2 infection. Long-term outcomes for people with diabetes previously hospitalised with COVID-19 are, however, unknown. This study aimed to determine the longer-term physical and mental health effects of COVID-19 in people with and without diabetes. Methods: The PHOSP-COVID study is a multicentre, long-term follow-up study of adults discharged from hospital between 1 February 2020 and 31 March 2021 in the UK following COVID-19, involving detailed assessment at 5 and 12 months after discharge. The association between diabetes status and outcomes were explored using multivariable linear and logistic regressions. Findings: People with diabetes who survived hospital admission with COVID-19 display worse physical outcomes compared to those without diabetes at 5- and 12-month follow-up. People with diabetes displayed higher fatigue (only at 5 months), frailty, lower physical performance, and health-related quality of life and poorer cognitive function. Differences in outcomes between diabetes status groups were largely consistent from 5 to 12-months. In regression models, differences at 5 and 12 months were attenuated after adjustment for BMI and presence of other long-term conditions. Interpretation: People with diabetes reported worse physical outcomes up to 12 months after hospital discharge with COVID-19 compared to those without diabetes. These data support the need to reduce inequalities in long-term physical and mental health effects of SARS-CoV-2 infection in people with diabetes. Funding: UK Research and Innovation and National Institute for Health Research. The study was approved by the Leeds West Research Ethics Committee (20/YH/0225) and is registered on the ISRCTN Registry (ISRCTN10980107). |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
eClinicalMedicine; https://qmro.qmul.ac.uk/xmlui/handle/123456789/103473 |
| DOI: |
10.1016/j.eclinm.2024.103005 |
| Availability: |
https://qmro.qmul.ac.uk/xmlui/handle/123456789/103473; https://doi.org/10.1016/j.eclinm.2024.103005 |
| Rights: |
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ; © 2024 The Author(s). Published by Elsevier Ltd |
| Accession Number: |
edsbas.BAAFA93B |
| Database: |
BASE |