| Title: |
Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex ; Cell Reports |
| Authors: |
Batten, Seth R.; Hartle, Alec E.; Barbosa, Leonardo S.; Hadj-Amar, Beniamino; Bang, Dan; Melville, Natalie; Twomey, Tom; White, Jason P.; Torres, Alexis; Celaya, Xavier; McClure, Samuel M.; Brewer, Gene A.; Lohrenz, Terry; Kishida, Kenneth T.; Bina, Robert W.; Witcher, Mark R.; Vannucci, Marina; Casas, Brooks; Chiu, Pearl; Montague, P. Read; Howe, W. Matt |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
VTechWorks (VirginiaTech) |
| Description: |
Words represent a uniquely human information channelhumans use words to express thoughts and feelings and to assign emotional valence to experience. Work from model organisms suggests that valence assignments are carried out in part by the neuromodulators dopamine, serotonin, and norepinephrine. Here, we ask whether valence signaling by these neuromodulators extends to word semantics in humans by measuring sub-second neuromodulator dynamics in the thalamus (N = 13) and anterior cingulate cortex (N = 6) of individuals evaluating positive, negative, and neutrally valenced words. Our combined results suggest that valenced words modulate neuromodulator release in both the thalamus and cortex, but with regionand valence-specific response patterns, as well as hemispheric dependence for dopamine release in the anterior cingulate. Overall, these experiments provide evidence that neuromodulator-dependent valence signaling extends to word semantics in humans, but not in a simple one-valence-per-transmitter fashion. ; We would also like to acknowledge our funding: Virginia Tech Foundation Seale Innovation Award (P.R.M.: FY22); Principal Research Fellowship funded by the Wellcome Trust (P.R.M.: 091188/Z/10/Z); Sir Henry Wellcome Postdoctoral Fellowship funded by the Wellcome Trust (D.B.: 213630/Z/18/Z); the Wellcome Centre for Human Neuroimaging, which is supported by core funding from the Wellcome Trust (D.B. and P.R.M.: 203147/Z/16/Z); the Lundbeck Foundation (D.B.: R368-2021-325); the Swartz Foundation (P.R.M.: 2019- 11); the NIH NCATS (K.T.K.: KL2TR001421); the NIH-NIDA (K.T.K.: R01- DA048096); the NIH-NINDS (K.T.K. and P.R.M.: R01-NS092701); the NIHNIMH (K.T.K.: R01-MH121099; K.T.K., M.V., and P.R.M.: R01-MH124115; P.C. and P.R.M.: R01-MH122512; B.C. and P.R.M.: R01-MH122948; and P.C.: R01-127773); VA-RR&D (B.C.: D2354R); and the NIH-NIA (W.M.H. and P.R.M.: R56 AG080735). ; Published version |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/10919/124182; https://doi.org/10.1016/j.celrep.2024.115162; 44 |
| DOI: |
10.1016/j.celrep.2024.115162 |
| Availability: |
https://hdl.handle.net/10919/124182; https://doi.org/10.1016/j.celrep.2024.115162 |
| Rights: |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.BAC97E7C |
| Database: |
BASE |