| Title: |
Effects of indoor environments and outdoor air pollutants in residential areas on acute exacerbation in patients with severe asthma |
| Authors: |
Kim, BK; Kim, HC; Lee, DW; Nam, YH; Sim, DW; Lee, Y; Shim, JS; Yang, MS; Kim, MH; Kim, SR; Kim, SH; Koh, YI; Park, HW; KoSAR investigators |
| Contributors: |
107733; Lee, Y |
| Publication Year: |
2025 |
| Subject Terms: |
Adult; Aged; Air Pollutants; Air Pollution; Indoor; Asthma; Environmental Exposure; Female; Humans; Male; Middle Aged; Particulate Matter; Tobacco Smoke Pollution; cooking; indoor air pollution; symptom flare up |
| Description: |
This study aimed to determine the effects of indoor environment (IE) and outdoor air pollutants (OAPs) in residential areas on acute exacerbation (AE) in patients with severe asthma. A total of 115 participants were recruited. To characterize IE, we used structured questionnaires and estimated OAP concentrations using a land-use regression model. Participants who were exposed to passive smoking and lived in houses where the kitchen and living room were not separated showed a significantly higher rate of AE (p = 0.014 and 0.0016, respectively). The mean concentration of PM(2.5) in residential areas during the last 3 years was significantly higher in participants with AE than that in those without AE (19.8 +/- 3.1 vs. 21.0 +/- 2.5 microg/m(3), p = 0.033). Moreover, the serum level of 8-hydroxy-2'-deoxyguanosine significantly increased in participants with AE compared to those without AE (56.9 +/- 30.0 vs. 94.7 +/- 44.5 ng/mL, p = 0.0047) suggesting enhanced oxidative stress in those with AE. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
J009603123; http://repository.ajou.ac.kr/handle/201003/34188 |
| DOI: |
10.1080/09603123.2024.2390474 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/34188; https://doi.org/10.1080/09603123.2024.2390474 |
| Accession Number: |
edsbas.BACEB81E |
| Database: |
BASE |