| Title: |
Higher early pregnancy plasma myo‐inositol associates with increased postprandial glycaemia later in pregnancy: Secondary analyses of the NiPPeR randomized controlled trial |
| Authors: |
Chan, Shiao‐Yng; Zhang, Han; Wong, Jui‐Tsung; Chang, Hsin F.; Chen, Ling‐Wei; Barton, Sheila J.; Nield, Heidi; El‐Heis, Sarah; Kenealy, Timothy; Lavalle, Luca; Ramos‐Nieves, J. Manuel; Godin, Jean‐Philippe; Silva‐Zolezzi, Irma; Cutfield, Wayne S.; Godfrey, Keith M. |
| Contributors: |
National Research Foundation Singapore; Medical Research Council; Agency for Science, Technology and Research |
| Source: |
Diabetes, Obesity and Metabolism ; volume 26, issue 5, page 1658-1669 ; ISSN 1462-8902 1463-1326 |
| Publisher Information: |
Wiley |
| Publication Year: |
2024 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Aim Myo ‐inositol supplementation from ~13 weeks' gestation reportedly improves glycaemia regulation in metabolically at‐risk women, with speculation that earlier supplementation might bring further improvement. However, the NiPPeR trial of a myo ‐inositol‐containing supplement starting preconception did not lower gestational glycaemia in generally healthy women. We postulated that the earlier timing of supplementation influences the maternal metabolic adaptation for gestational glycaemia regulation. Methods In total, 585 women were recruited from Singapore, UK and New Zealand for the NiPPeR study. We examined associations of plasma myo ‐inositol concentrations at 7 and 28 weeks' gestation with 28 weeks plasma glucose (PG; fasting, and 1 h and 2 h in 75 g oral glucose tolerance test) and insulin indices using linear regression adjusting for covariates. Results Higher 7‐week myo ‐inositol, but not 28‐week myo ‐inositol, associated with higher 1 h PG [β adj (95% confidence intervals) 0.05 (0.01, 0.09) log e mmol/L per log e μmol/L, p = .022] and 2 h PG [0.08 (0.03, 0.12), p = .001]; equivalent to 0.39 mmol/L increase in 2 h PG for an average 7‐week myo ‐inositol increase of 23.4 μmol/L with myo ‐inositol supplementation. Higher 7‐week myo ‐inositol associated with a lower 28‐week Stumvoll index (first phase), an approximation of insulin secretion [−0.08 (−0.15, −0.01), p = .020] but not with 28‐week Matsuda insulin sensitivity index. However, the clinical significance of a 7‐week myo ‐inositol‐related increase in glycaemia was limited as there was no association with gestational diabetes risk, birthweight and cord C‐peptide levels. In‐silico modelling found higher 28‐week myo ‐inositol was associated with lower gestational glycaemia in White, but not Asian, women after controlling for 7‐week myo ‐inositol effects. Conclusion To our knowledge, our study provides the first evidence that increasing first trimester plasma myo ‐inositol may slightly exacerbate later pregnancy post‐challenge glycaemia, ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/dom.15468 |
| Availability: |
https://doi.org/10.1111/dom.15468 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.BADD88B0 |
| Database: |
BASE |