| Title: |
Machine learning-enabled systematic review on coded healthcare data in heart failure research |
| Authors: |
Champsi,Asgher; Slater,Karin T; Gill,Simrat; Dyszynski,Tomasz; Schröder,Megan; Suzart-Woischnik,Kiliana; Tyl,Benoit; Allée,Guillaume; Sartorius,Alfonso; Lumbers,R Thomas; Asselbergs, Folkert W; Grobbee, Diederick E; Gkoutos,Georgios; Kotecha, Dipak; Global Health; Circulatory Health; JC onderzoeksprogramma Cardiovascular Health |
| Publication Year: |
2026 |
| Subject Terms: |
Journal Article |
| Description: |
AIMS: Coded healthcare data are now commonly used in clinical research. This study aimed to assess the transparency of reporting within heart failure studies and employ machine learning to facilitate larger-scale evaluation. METHODS & RESULTS: A systematic search of EMBASE and MEDLINE (2015-2020) identified 4279 heart failure studies with accessible Extensible Markup Language published in the top 25 journals by impact factor. Manual extraction in a random sample of 170 studies by independent human reviewers characterized 40 studies (23.5%) that used coded healthcare data, with 34 of these (85%) reporting doing so and only 19 (47.5%) providing clear descriptions of dataset construction and linkage. Another 420 studies underwent manual annotation to further train a Natural Language Processing (NLP) model designed for this study to automate and upscale review. The NLP model processed 3689 studies with a high level of internal accuracy (area under the receiver operating characteristic curve 0.97 and F1 score 0.96). Overall, the NLP approach identified 782 studies (21.2%) that reported coded healthcare data usage (95% CI 19.8-20.9%). No correlation was found between the reporting of coded healthcare data use and the publication year (r = -0.05; P = 0.21) or citation count (r = -0.13; P = 0.12). CONCLUSION: One-fifth of contemporary heart failure research articles are already reporting the use of coded healthcare data, with at-scale evaluation facilitated by a machine-learning model. The limited transparency on how coded healthcare data were used in studies highlights the need for quality standards such as the CODE-EHR framework for the use of healthcare data in research. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2634-3916 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/469258 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/469258 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.BB297E51 |
| Database: |
BASE |