| Title: |
Child Opportunity Index at birth and asthma with recurrent exacerbations in the US ECHO program |
| Authors: |
Miller, Rachel L; Schuh, Holly; Chandran, Aruna; Habre, Rima; Angal, Jyoti; Aris, Izzuddin M M; Aschner, Judy L; Bendixsen, Casper G; Blossom, Jeffrey; Bosquet-Enlow, Michelle; Breton, Carrie V; Camargo, Carlos A; Carroll, Kecia N; Commodore, Sarah; Croen, Lisa A; Dabelea, Dana M; Deoni, Sean C. L.; Ferrara, Assiamira; Fry, Rebecca C; Ganiban, Jody M; Geiger, Sarah D; Gern, James E; Gilliland, Frank D; Gogcu, Semsa; Gold, Diane R; Hare, Marion E; Harte, Robyn N; Hartert, Tina V; Hertz-Picciotto, Irva; Hipwell, Alison E; Jackson, Daniel J; Karagas, Margaret K; Khurana Hershey, Gurjit K; Kim, Haejin; Litonjua, Augusto A; Marsit, Carmen J; McEvoy, Cynthia T; Mendonça, Eneida A; Moore, Paul E; Nguyen, Anh P; Nkoy, Flory L; O'Connor, Thomas G; Oken, Emily; Ownby, Dennis R; Perzanowski, Matthew; Rivera-Spoljaric, Katherine; Sathyanarayana, Sheela; Singh, Anne Marie; Stanford, Joseph B; Stroustrup, Annemarie; Towe-Goodman, Nissa; Wang, Veronica A; Woodruff, Tracey J; Wright, Robert O; Wright, Rosalind J; Zanobetti, Antonella; Zoratti, Edward M; Johnson, Christine C |
| Source: |
Public Health Sciences Articles |
| Publisher Information: |
Henry Ford Health Scholarly Commons |
| Publication Year: |
2025 |
| Collection: |
Henry Ford Health System Scholarly Commons |
| Subject Terms: |
Child; Preschool; Female; Humans; Infant; Male; Asthma/epidemiology; Black or African American; Environmental Exposure/adverse effects; Incidence; Neighborhood Characteristics; Recurrence; United States/epidemiology; White; Asthma; child opportunity index; environmental and social determinants of asthma; incidence rates; recurrent asthma exacerbations |
| Description: |
BACKGROUND: Environmental exposures and social determinants likely influence specific childhood asthma phenotypes. OBJECTIVE: We hypothesized that the Child Opportunity Index (COI) at birth, measuring multiple neighborhood opportunities, influences incidence rates (IRs) for asthma with recurrent exacerbations (ARE). METHODS: We tested for COI associations with ARE IRs in 15,877 children born between 1990 and 2018 in the ECHO (Environmental Influences on Child Health Outcomes) program. Parent-reported race and ethnicity and other demographics were assessed as effect modifiers. RESULTS: The IRs of ARE for children born in very low COI neighborhoods was higher (IR = 10.98; 95% CI: 9.71, 12.25) than for other COI categories. Rates for non-Hispanic Black (NHB) children were significantly higher than non-Hispanic White children in every COI category. The ARE IRs for children born in very low COI neighborhoods were several-fold higher for NHB and Hispanic Black children (IR = 15.30; 95% CI: 13.10, 17.49; and IR = 18.48; 95% CI: 8.80, 28.15, respectively) when compared to White children. Adjusting for individual-level characteristics, children born in very low COI neighborhoods demonstrated an ARE IR ratio of 1.26 (95% CI: 0.99, 1.59) with a higher incidence of cases among children ages 2 to 4 years and with a parental history of asthma. CONCLUSIONS: Rates of ARE were higher among children born in under-resourced communities, and this relationship is strongest for young minoritized children with a parental history of asthma. Higher rates for NHB even in the highest COI categories suggest that risk associated with race persists regardless of social disadvantage. |
| Document Type: |
text |
| Language: |
unknown |
| Relation: |
https://scholarlycommons.henryford.com/publichealthsciences_articles/600; https://libkey.io/libraries/106/40089117 |
| Availability: |
https://scholarlycommons.henryford.com/publichealthsciences_articles/600; https://libkey.io/libraries/106/40089117 |
| Accession Number: |
edsbas.BB2FCB51 |
| Database: |
BASE |