| Title: |
Breast cancer mortality in 500 000 women with early invasive breast cancer in England, 1993-2015: population based observational cohort study |
| Authors: |
Taylor, Carolyn; McGale, Paul; Probert, Jake; Broggio, John; Charman, Jackie; Darby, Sarah C; Kerr, Amanda J; Whelan, Timothy; Cutter, David J; Mannu, Gurdeep; Dodwell, David |
| Publisher Information: |
BMJ Publishing Group Ltd |
| Publication Year: |
2023 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
RESEARCH |
| Description: |
Objectives To describe long term breast cancer mortality among women with a diagnosis of breast cancer in the past and estimate absolute breast cancer mortality risks for groups of patients with a recent diagnosis. Design Population based observational cohort study. Setting Routinely collected data from the National Cancer Registration and Analysis Service. Participants All 512 447 women registered with early invasive breast cancer (involving only breast and possibly axillary nodes) in England during January 1993 to December 2015, with follow-up to December 2020. Main outcome measures Annual breast cancer mortality rates and cumulative risks by time since diagnosis, calendar period of diagnosis, and nine characteristics of patients and tumours. Results For women with a diagnosis made within each of the calendar periods 1993-99, 2000-04, 2005-09, and 2010-15, the crude annual breast cancer mortality rate was highest during the five years after diagnosis and then declined. For any given time since diagnosis, crude annual breast cancer mortality rates and risks decreased with increasing calendar period. Crude five year breast cancer mortality risk was 14.4% (95% confidence interval 14.2% to 14.6%) for women with a diagnosis made during 1993-99 and 4.9% (4.8% to 5.0%) for women with a diagnosis made during 2010-15. Adjusted annual breast cancer mortality rates also decreased with increasing calendar period in nearly every patient group, by a factor of about three in oestrogen receptor positive disease and about two in oestrogen receptor negative disease. Considering just the women with a diagnosis made during 2010-15, cumulative five year breast cancer mortality risk varied substantially between women with different characteristics: it was |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://www.bmj.com/cgi/content/short/381/jun13_1/e074684; http://dx.doi.org/10.1136/bmj-2022-074684 |
| DOI: |
10.1136/bmj-2022-074684 |
| Availability: |
http://www.bmj.com/cgi/content/short/381/jun13_1/e074684; https://doi.org/10.1136/bmj-2022-074684 |
| Rights: |
Copyright (C) 2023, BMJ Publishing Group Ltd |
| Accession Number: |
edsbas.BBAE1853 |
| Database: |
BASE |