| Description: |
Background and Aim: Accelerated platelet breakdown and decreased platelet synthesis are major causes of thrombocytopenia in immune thrombocytopenic purpura (ITP). In our study, thrombocytopenia instances were classified as hypoproductive, megaloblastic, or hyperdestructive. Our study aims to assess the prevalence of IPF and its importance in various thrombocytopenic groups, with the hope that it can be used as a new emerging prognostic marker in identifying and managing such patients. Material and Methods: 50 thrombocytopenia samples were collected and analysed. Based on the history and final diagnosis, all patients were classified as megaloblastic, hypoproduction, or hyperdestruction. In a k3 EDTA vacutainer, peripheral blood samples were obtained. All samples were analysed within four hours of being collected. All samples had their platelet counts and IPF% determined. Results: The findings revealed that 40% of the 50 cases evaluated were men and 60% were females, with a small female preponderance. The majority of patients were between the ages of 20 and 39. In the Hyperdestructive group, 27 (93.10%) of the 50 cases exhibited increased IPF, but in the Hypoproductive group, only 01 (0.09%) of the 11 cases showed increased IPF. ITP had the highest IPF%, followed by malaria and dengue. Conclusion: Immature Platelet Fraction is a straightforward non-invasive approach for calculating the proportion of reticulated platelets in peripheral blood in order to monitor megakaryocytic activity. IPF is much higher in the hyper destructive group, indicating enhanced thrombopoiesis, and its value is inversely related to platelet count in these situations. ; Background and Aim: Accelerated platelet breakdown and decreased platelet synthesis are major causes of thrombocytopenia in immune thrombocytopenic purpura (ITP). In our study, thrombocytopenia instances were classified as hypoproductive, megaloblastic, or hyperdestructive. Our study aims to assess the prevalence of IPF and its importance in various thrombocytopenic groups, ... |