| Title: |
DALIA- a comprehensive resource of Disease Alleles in Arab population |
| Authors: |
Vatsyayan, Aastha; Sharma, Parul; Gupta, Shrey; Sandhu, Sumiti; Venu, Seetha Lakshmi; Sharma, Vandana; Badaoui, Bouabid; Azedine, Kaidi; Youssef, Serti; Rajab, Anna; Fayez, Alaaeldin; Madinur, Seema; Ranawat, Anop; Pandhare, Kavita; Ramachandran, Srinivasan; Sivasubbu, Sridhar; Scaria, Vinod |
| Contributors: |
Bandapalli, Obul Reddy; Council of Scientific and Industrial Research, India |
| Source: |
PLOS ONE ; volume 16, issue 1, page e0244567 ; ISSN 1932-6203 |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2021 |
| Collection: |
PLOS Publications (via CrossRef) |
| Description: |
The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1371/journal.pone.0244567 |
| Availability: |
https://doi.org/10.1371/journal.pone.0244567; https://dx.plos.org/10.1371/journal.pone.0244567 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.BBC77776 |
| Database: |
BASE |