| Title: |
Genomic characterization of host factors related to SARS-CoV-2 infection in people with dementia and control populations: The GR@ACE/DEGESCO study. |
| Authors: |
De Rojas, I; Hernández, I; Montrreal, L; Quintela, I; Calero, M; Royo, JL; Huerto Vilas, R; González-Pérez, A; Franco-Macías, E; Macías, J; Menéndez-González, M; Frank-García, A; Diez-Fairen, M; Lage, C; García-Madrona, S; Aguilera, N; García-González, P; Puerta, R; Sotolongo-Grau, O; Alonso-Lana, S; Rábano, A; Arias Pastor, A; Pastor, AB; Corma-Gómez, A; Martín Montes, A; Martínez Rodríguez, C; Buiza-Rueda, D; Periñán, MT; Rodriguez-Rodriguez, E; Alvarez, I; Rosas Allende, I; Pineda, JA; Bernal Sánchez-Arjona, M; Fernández-Fuertes, M; Mendoza, S; Del Ser, T; Gr Ace/Degesco Consortium; Garcia-Ribas, G; Sánchez-Juan, P; Pastor, P; Bullido, MJ; Álvarez, V; Real, LM; Mir, P; Piñol-Ripoll, G; García-Alberca, JM; Medina, M; Orellana, A; Butler, CR; Marquié, M; Sáez, ME; Carracedo, Á; Tárraga, L; Boada, M; Ruiz, A |
| Source: |
11 ; 1 |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2021 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
APOE; COVID-19; GR@ACE/DEGESCO; GWAS; SARS-CoV-2; dementia |
| Subject Geographic: |
Switzerland |
| Description: |
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Journal of Personalized Medicine; http://hdl.handle.net/10044/1/93362 |
| DOI: |
10.3390/jpm11121318 |
| Availability: |
http://hdl.handle.net/10044/1/93362; https://doi.org/10.3390/jpm11121318 |
| Rights: |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.BC27F31A |
| Database: |
BASE |