| Title: |
A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry |
| Authors: |
Darst, Burcu F; Wan, Peggy; Sheng, Xin; Bensen, Jeannette T; Ingles, Sue A; Rybicki, Benjamin A; Nemesure, Barbara; John, Esther M; Fowke, Jay H; Stevens, Victoria L; Berndt, Sonja I; Huff, Chad D; Strom, Sara S; Park, Jong y; Zheng, Wei; Ostrander, Elaine A; Walsh, Patrick C; Srivastava, Shiv; Carpten, John; Sellers, Thomas A; Yamoah, Kosj; Murphy, Adam B; Sanderson, Maureen; Crawford, Dana C; Gapstur, Susan M; Bush, William S; Aldrich, Melinda C; Cussenot, Olivier; Yeager, Meredith; Petrovics, Gyorgy; Cullen, Jennifer; Neslund-Dudas, Christine; Kittles, Rick A; Xu, Jianfeng; Stern, Mariana C; Kote-Jarai, Zsofia; Govindasami, Koveela; Chokkalingam, Anand P; Multigner, Luc; Parent, Marie-Elise; Menegaux, Florence; Cancel-Tassin, Geraldine; Kibel, Adam S; Klein, Eric A; Goodman, Phyllis J; Drake, Bettina F; Hu, Jennifer J; Clark, Peter E; Blanchet, Pascal; Casey, Graham; Hennis, Anselm J M; Lubwama, Alexander; Jr, Ian M Thompson; Leach, Robin; Gundell, Susan M; Pooler, Loreall; Xia, Lucy; Mohler, James L; Fontham, Elizabeth T H; Smith, Gary J; Taylor, Jack A; Eeles, Rosalind A; Brureau, Laurent; Chanock, Stephen J; Watya, Stephen; Stanford, Janet L; Mandal, Diptasri; Isaacs, William B; Cooney, Kathleen; Blot, William J; Conti, David V; Haiman, Christopher A |
| Contributors: |
University of Southern California (USC); Centre de Recherche pour les Pathologies Prostatiques. (CeRePP / UA 3104); CEREPP; CHU Tenon AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU Pointe-à-Pitre / Abymes Guadeloupe; U19 CA148537, U19 CA214253, R01 CA165862, and K99 CA246063, National Cancer Institute at the National Institutes of Health |
| Source: |
ISSN: 0302-2838. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2020 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Prostate cancer; Health disparities; Genetics; Genetic variant; Family history; Familial prostate cancer; African ancestry; 8q24; [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or mutations have been identified that contribute to familial clustering of PCa in this population. We investigated whether the African ancestry-specific PCa risk variant at 8q24, rs72725854, is enriched in men with a PCa family history in 9052 cases, 143 cases from high-risk families, and 8595 controls of African ancestry. We found the risk allele to be significantly associated with earlier age at diagnosis, more aggressive disease, and enriched in men with a PCa family history (32% of high-risk familial cases carried the variant vs 23% of cases without a family history and 12% of controls). For cases with two or more first-degree relatives with PCa who had at least one family member diagnosed at age |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32409115; PUBMED: 32409115 |
| DOI: |
10.1016/j.eururo.2020.04.060 |
| Availability: |
https://univ-rennes.hal.science/hal-02860251; https://univ-rennes.hal.science/hal-02860251v1/document; https://univ-rennes.hal.science/hal-02860251v1/file/hal-02860251.pdf; https://doi.org/10.1016/j.eururo.2020.04.060 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.BC2BFEC8 |
| Database: |
BASE |