| Title: |
Larval diet affects mosquito development and permissiveness to Plasmodium infection |
| Authors: |
Gendrin, MEM; Christophides; Linenberg, Inbar |
| Contributors: |
Biotechnology and Biological Sciences Research Council (BBSRC) |
| Publisher Information: |
Nature Publishing Group |
| Publication Year: |
2016 |
| Collection: |
Imperial College London: Spiral |
| Description: |
The larval stages of malaria vector mosquitoes develop in water pools, feeding mostly on microorganisms and environmental detritus. Richness in the nutrient supply to larvae influences the development and metabolism of larvae and adults. Here, we investigated the effects of larval diet on the development, microbiota content and permissiveness to Plasmodium of Anopheles coluzzii . We tested three fish diets often used to rear mosquitoes in the laboratory, including two pelleted diets, Dr. Clarke’s Pool Pellets and Nishikoi Fish Pellets , and one flaked diet, Tetramin Fish-Flakes. Larvae grow and develop faster and produce bigger adults when feeding on both types of pellets compared with flakes. This correlates with a higher microbio ta load in pellet-fed larv ae, in agreement with the known positive effect of the microbiota on mosq uito development. Larval diet also significantly influences the prevalence and intensity of Plasmodium berghei infection in adults, whereby Nishikoi Fish Pellets -fed larvae develop into adults that are highly permissive to parasites and survive longer after infection . This correlates with a lower amount of Enterobacteriaceae in the midgut microbiota. Together, our results shed light on the influenc e of larval feeding on mosquito development, microbiota and vector competence ; they also provide useful data for mosquito rearing. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
Scientific Reports; http://hdl.handle.net/10044/1/42443; https://dx.doi.org/10.1038/srep38230; BB/k009338/1 |
| DOI: |
10.1038/srep38230 |
| Availability: |
http://hdl.handle.net/10044/1/42443; https://doi.org/10.1038/srep38230 |
| Rights: |
© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.BC75145F |
| Database: |
BASE |