| Title: |
Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer |
| Authors: |
Simar-Mentieres, Sophie; Nesslany, Fabrice; Sola, Marie-Laure; Mortier, Sandra; Raimbault, Jean-Michel; Gondelle, F.; Chabot, L.; Pandard, Pascal; Wils, Daniel; Chentouf, Aouatif |
| Contributors: |
Université de Lille; CHU Lille; Institut Pasteur de Lille; Laboratoire de toxicologie génétique Lille; European Research Biology Center ERBC; Institut National de l'Environnement Industriel et des Risques INERIS; Roquette Frères |
| Publisher Information: |
Hindawi Limited |
| Publication Year: |
2022 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Description: |
Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. These phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSORB® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed. The company can now offer PVC manufacturers a new product which competes with phthalates and other such chemicals. The market for plasticizers is very important, and ROQUETTE intends to provide a more sustainable and safer product. Isosorbide diester is bio-based (made from glucose and vegetable fatty acids). This plasticizer is registered in REACH regulation for high volumes (>1000 T/year). Risk assessment was obtained by conducting a wide range of biodegradability and toxicological protocols, using rodent models, according to established guidelines. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB® ID 37 is nontoxic to mammalian life and is readily biodegradable. ; 2021 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/rdf+xml; charset=utf-8; application/octet-stream |
| Language: |
unknown |
| Relation: |
Journal of Toxicology; http://hdl.handle.net/20.500.12210/74224 |
| Availability: |
https://hdl.handle.net/20.500.12210/74224 |
| Rights: |
Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.BC796A72 |
| Database: |
BASE |