| Title: |
Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study |
| Authors: |
Giacomazzi, Juliana; Ziegelmann, Patricia Klarmann; Costa, Samanta da; Bittar, Camila Matzenbacher; Obst, Fernando Mariano; Rosset, Clévia; Macedo, Gabriel Souza; Bock, Hugo; Canal, Thais; Paese, Mari Ines; Benvenuti , Jean Lucas; Buj, Maria Carolina; Prolla, Patrícia Ashton; Goldim, José Roberto; Pozza, Roberta |
| Publication Year: |
2023 |
| Collection: |
Universidade Federal do Rio Grande do Sul (UFRGS): Lume |
| Subject Terms: |
Fatores de risco; Cancer : Diagnostico precoce; Cancer risk factors; Hereditary cancer syndrome (HCS); Multigene panel testing (MGPT); Family history of cancer |
| Description: |
Purpose: To evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years and to characterize them for hereditary cancer syndrome (HCS) phenotypes. Methods: A case-control (matched by age group and sex) study was conducted on regional cancer. Data on exposure factors and first-/second-degree family history of cancer (1/2FHC) were collected. The MGPT was performed using Illumina next-generation sequencing technology. Results: A total of 1,007 cases and 1,007 controls were included. The most frequent cancers were BC (n = 311), CCR (n = 147), prostate (n = 132), and lung cancers (n = 89). It was independently associated with cancer, 1/2FHC, tobacco consumption (TC), pesticide exposure (PE), solvent/glue exposure, and BMI |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
JCO Global Oncology. United States. Vol. 9 (Dec. 2023), e2300006, 17 p.; https://hdl.handle.net/10183/296494; 001292255 |
| Availability: |
https://hdl.handle.net/10183/296494 |
| Rights: |
Open Access |
| Accession Number: |
edsbas.BC9ADBD5 |
| Database: |
BASE |