| Title: |
CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study |
| Authors: |
Lang, Sean M.; Truong, Dongngan T.; Powell, Andrew J.; Kazlova, Valiantsina; Newburger, Jane W.; Awerbach, Jordan D.; Binka, Edem; Bradford, Tamara T.; Cartoski, Mark; Cheng, Andrew; DiLorenzo, Michael P.; Dionne, Audrey; Dorfman, Adam L.; Elias, Matthew D.; Garuba, Olukayode; Gerardin, Jennifer F.; Hasbani, Keren; Jone, Pei-Ni; Lam, Christopher Z.; Misra, Nilanjana; Morgan, Lerraughn M.; Nutting, Arni; Patel, Jyoti K.; Robinson, Joshua D.; Schuchardt, Eleanor L.; Sexson Tejtel, Kristen; Singh, Gautam K.; Slesnick, Timothy C.; Trachtenberg, Felicia; Taylor, Michael D.; Pearson, Gail; Pemberton, Victoria; Burns, Kristin; Freemon, D’Andrea; Miller, Julie; Hayes, Kerri; Crosby-Thompson, Allison; Amarnath, Ayesha; Ambrosoli, James; Artis, Cassandra; Rubio, Kay; Kinhikar, Chitra; Marshall, Amanda; Mu, PJ; Mbiydzenyuy, Devine; Hu, Chenwei; Eyob, Lozan; Slayton, Beverly; DiStefano, Lauren |
| Source: |
Circulation: Cardiovascular Imaging ; volume 18, issue 9 ; ISSN 1941-9651 1942-0080 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Description: |
BACKGROUND: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of patients with Multisystem Inflammatory Syndrome in Children. METHODS: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement. RESULTS: A total of 263 CMRs from 255 patients with Multisystem Inflammatory Syndrome in Children were analyzed. The mean patient age was 11.4±4.4 years. Most studies were performed at 3 months (33%) or 6 months (45%) after hospitalization. Left ventricular dysfunction was present in 17 (6.7%) of the first CMRs and was never worse than mild. Dysfunction was observed in 4/7 (57%) patients at admission, 5/87 (6.9%) patients at 3 months, and 6/129 (4.6%) patients imaged either at 6 months or 1 year post-hospitalization. Late gadolinium enhancement was present in 2 (0.8%) patients, 1 at 3 months and another at 6 months following hospitalization. Coronary artery dilation was present in 13 of the 174 (7.5%) patients. Nine patients met the Lake Louise criteria for myocarditis (3.5%) at the time of CMR. CONCLUSIONS: In this largest published multiinstitutional longitudinal CMR evaluation of confirmed patients with Multisystem Inflammatory Syndrome in Children, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT05287412. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/circimaging.124.017420 |
| DOI: |
10.1161/CIRCIMAGING.124.017420 |
| Availability: |
https://doi.org/10.1161/circimaging.124.017420; https://www.ahajournals.org/doi/full/10.1161/CIRCIMAGING.124.017420 |
| Accession Number: |
edsbas.BCBAC41E |
| Database: |
BASE |