| Title: |
Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years |
| Authors: |
Lyons-Reid, Jaz; Derraik, José G. B.; Kenealy, Timothy; Albert, Benjamin B.; Ramos Nieves, J. Manuel; Monnard, Cathriona R.; Titcombe, Phil; Nield, Heidi; Barton, Sheila J.; El-Heis, Sarah; Tham, Elizabeth; Godfrey, Keith M.; Chan, Shiao-Yng; Cutfield, Wayne S.; Carvalho, Ryan; Castro, Julie Ann; Cavanagh, Mary; Chang, Hsin Fang; Chong, Yap Seng; Costello, Paula; Cox, Vanessa; Galani, Sevasti; Hammond, Judith; Harvey, Nicholas C.; Han, Soo Min; Jagtap, Mrunalini; Nembrini, Chiara; O’Sullivan, Justin M.; Ong, Judith; Silva-Zolezzi, Irma; Sim, Wendy; Tay, Vicky; Tint, Mya-Thway; Vickers, Mark; Wong, Jui-Tsung; Woon, Gladys; Yuan, Wen Lun |
| Contributors: |
National Institute for Health and Care Research; National Institute for Health Research Southampton Biomedical Research Centre; British Heart Foundation; Erasmus+; National Medical Research Council; Medical Research Council; National Research Foundation Singapore; National University of Singapore; Agency for Science, Technology and Research |
| Source: |
BMC Medicine ; volume 22, issue 1 ; ISSN 1741-7015 |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2024 |
| Description: |
Background Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this. Methods Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo -inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis. Results At 2 years, there was a trend towards lower mean BMI among intervention offspring (adjusted mean difference [aMD] − 0.14 SD [95% CI 0.30, 0.02], p = 0.09), and fewer had a BMI > 95th percentile (i.e. > 1.65 SD, 9.2% vs 18.0%, adjusted risk ratio [aRR] 0.51 [95% CI 0.31, 0.82], p = 0.006). Longitudinal data revealed that intervention offspring had a 24% reduced risk of experiencing rapid weight gain > 0.67 SD in the first year of life (21.9% vs 31.1%, aRR 0.76 [95% CI 0.58, 1.00], p = 0.047). The risk was likewise decreased for sustained weight gain > 1.34 SD in the first 2 years of life (7.7% vs 17.1%, aRR 0.55 [95% CI 0.34, 0.88], p = 0.014). From five weight gain trajectories identified, there were more intervention offspring in the “normal” weight gain trajectory characterised by stable weight SDS around 0 SD from birth to 2 years (38.8% vs 30.1%, RR 1.29 [95% CI 1.03, 1.62], p = 0.029). Conclusions Supplementation with myo -inositol, probiotics, and additional micronutrients preconception and in pregnancy reduced the incidence of rapid weight gain and obesity at 2 years among offspring. Previous reports suggest these effects will ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s12916-024-03246-w |
| DOI: |
10.1186/s12916-024-03246-w.pdf |
| DOI: |
10.1186/s12916-024-03246-w/fulltext.html |
| Availability: |
http://dx.doi.org/10.1186/s12916-024-03246-w; https://link.springer.com/content/pdf/10.1186/s12916-024-03246-w.pdf; https://link.springer.com/article/10.1186/s12916-024-03246-w/fulltext.html |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.BCE1EC05 |
| Database: |
BASE |