| Title: |
The individual’s signature of telomere length distribution |
| Authors: |
Toupance, Simon; Villemonais, Denis; Germain, Daphné; Gégout-Petit, Anne; Albuisson, Eliane; Benetos, Athanase |
| Contributors: |
Défaillance Cardiovasculaire Aiguë et Chronique (DCAC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Institut Élie Cartan de Lorraine (IECL); Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS); Ecole Nationale Supérieure des Mines de Nancy (ENSMN); Institut Mines-Télécom Paris (IMT)-Université de Lorraine (UL); TO Simulate and CAlibrate stochastic models (TOSCA); Centre Inria d'Université Côte d'Azur; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Élie Cartan de Lorraine (IECL); Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS); Biology, genetics and statistics (BIGS); Centre Inria de l'Université de Lorraine; ESPRI-Biobase CHRU Nancy (Unité fonctionnelle de la plateforme d’aide à la recherche clinique); This work was supported by the French national program PHRC 2010-A01399-30, the regional project CPER-ITM2P 2015-2020, the French PIA project « Lorraine Université d’Excellence », reference ANR-15-IDEX-04-LUE and the Investments for the Future program under grant agreement No. ANR-15-RHU-0004; IMPACT GEENAGE; ANR-15-IDEX-0004,LUE,Isite LUE(2015); ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015) |
| Source: |
ISSN: 2045-2322. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2019 |
| Collection: |
Université de Lorraine: HAL |
| Subject Terms: |
ADELAHYDE study; Leukocyte telomere length distribution (LTLD); Telomere length; LTLD signature; [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology; [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry; Molecular Biology/Molecular biology; [STAT.AP]Statistics [stat]/Applications [stat.AP]; [STAT]Statistics [stat] |
| Description: |
International audience ; Mean telomere length in human leukocyte DNA samples reflects the different lengths of telomeres at the ends of the 23 chromosomes and in an admixture of cells. However, only rudimentary information is available regarding the distribution of telomere lengths in all chromosomes and the different cell types in leukocyte samples. Understanding the configuration of leukocyte telomere length distribution (LTLD) could be helpful in capturing intrinsic elements that are not provided by the mean leukocyte telomere length (mLTL). The objective of this study was to analyse LTLD and its temporal variation in adults. Leukocyte samples were donated on two occasions (8 years apart) by 72 participants in the ADELAHYDE study. Telomere length was measured by Southern blotting of the terminal restriction fragments. Individuals with comparable mLTLs displayed different shapes of LTLDs. Inter-individual variation in LTLD shape was much larger than intra-individual variation in LTLD shape between baseline and follow-up leukocyte samples. These results show an important individual stability of LTLD shape over time indicating that each individual has a characteristic LTLD signature. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/30679552; PUBMED: 30679552; PUBMEDCENTRAL: PMC6345926 |
| DOI: |
10.1038/s41598-018-36756-8 |
| Availability: |
https://inria.hal.science/hal-01925000; https://inria.hal.science/hal-01925000v1/document; https://inria.hal.science/hal-01925000v1/file/s41598-018-36756-8.pdf; https://doi.org/10.1038/s41598-018-36756-8 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.BCF90235 |
| Database: |
BASE |