| Title: |
Clinical Outcomes of Surgical Pulmonary Valve Replacement After Repair of Tetralogy of Fallot and Potential Prognostic Value of Preoperative Cardiopulmonary Exercise Testing |
| Authors: |
Babu-Narayan, Sonya V.; Diller, Gerhard-Paul; Gheta, Radu R.; Bastin, Anthony J.; Karonis, Theodoros; Li, Wei; Pennell, Dudley J.; Uemura, Hideki; Sethia, Babulal; Gatzoulis, Michael A.; Shore, Darryl F. |
| Source: |
Circulation ; volume 129, issue 1, page 18-27 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2014 |
| Description: |
Background— Indications for surgical pulmonary valve replacement (PVR) after repair of tetralogy of Fallot have recently been broadened to include asymptomatic patients. Methods and Results— The outcomes of PVR in adults after repair of tetralogy of Fallot at a single tertiary center were retrospectively studied. Preoperative cardiopulmonary exercise testing was included. Mortality was the primary outcome measure. In total, 221 PVRs were performed in 220 patients (130 male patients; median age, 32 years; range, 16–64 years). Homografts were used in 117 patients, xenografts in 103 patients, and a mechanical valve in 1 patient. Early (30-day) mortality was 2%. Overall survival was 97% at 1 year, 96% at 3 years, and 92% at 10 years. Survival after PVR in the later era (2005–2010; n=156) was significantly better compared with survival in the earlier era (1993–2004; n=65; 99% versus 94% at 1 year and 98% versus 92% at 3 years, respectively; P =0.019). Earlier era patients were more symptomatic preoperatively ( P =0.036) with a lower preoperative peak oxygen consumption (peak o 2 ; P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/circulationaha.113.001485 |
| DOI: |
10.1161/CIRCULATIONAHA.113.001485 |
| Availability: |
https://doi.org/10.1161/circulationaha.113.001485; https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.113.001485 |
| Accession Number: |
edsbas.BCFC0503 |
| Database: |
BASE |