| Title: |
Markers of inflammation and CD8 T‐cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV‐infected individuals |
| Authors: |
Longenecker, CT; Funderburg, NT; Jiang, Y; Debanne, S; Storer, N; Labbato, DE; Lederman, MM; McComsey, GA |
| Source: |
HIV Medicine ; volume 14, issue 6, page 385-390 ; ISSN 1464-2662 1468-1293 |
| Publisher Information: |
Wiley |
| Publication Year: |
2013 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objectives The aim of the study was to explore the relationships between lymphocyte and monocyte activation, inflammation, and subclinical vascular disease among HIV ‐1‐infected patients on antiretroviral therapy ( ART ). Methods Baseline mean common carotid artery ( CCA ) intima‐media thickness ( IMT ) and carotid plaque ( IMT > 1.5cm) were evaluated in the first 60 subjects enrolled in the S topping A therosclerosis and T reating U nhealthy B one with R osuvastatin in HIV ( SATURN‐HIV ) trial. All subjects were adults on stable ART with evidence of heightened T ‐cell activation ( CD8 + CD38 + HLA‐DR + ≥ 19%) or increased inflammation (high‐sensitivity C ‐reactive protein ≥ 2mg/ L ). All had fasting low‐density lipoprotein ( LDL ) cholesterol ≤ 130mg/ dL . Results Seventy‐eight per cent of patients were men and 65% were A frican‐ A merican. Median (interquartile range) age and CD 4 count were 47 (43, 52) years and 648 (511, 857) cells/ μL , respectively. All had HIV ‐1 RNA < 400 HIV ‐1 RNA copies/ mL . Mean CCA‐IMT was correlated with log‐transformed CD8 + CD38 + HLA‐DR + percentage ( r=0.326; P=0.043), and concentrations of interleukin‐6 ( r=0.283; P=0.028), soluble vascular cell adhesion molecule (sVCAM; r=0.434; P=0.004), tumour necrosis factor‐α receptor‐ I ( TNFR ‐ I ; r=0.591; P < 0.0001) and fibrinogen ( r=0.257; P=0.047). After adjustment for traditional cardiovascular disease ( CVD ) risk factors, the association with TNFR ‐ I ( P=0.007) and fibrinogen ( P=0.033) remained significant. Subjects with plaque ( n = 22; 37%) were older [mean (standard deviation) 51 (7.7) vs. 43 (9.4) years, respectively; P = 0.002], and had a higher CD8 + CD38 + HLA‐DR + percentage [median (interquartile range) 31% (24, 41%) vs. 23% (20, 29%), respectively; P = 0.046] and a higher sVCAM concentration [mean (standard deviation) 737 (159) vs. 592 (160) ng/ mL , respectively; P = 0.008] compared with those without plaque. Pro‐inflammatory monocyte subsets and serum markers of monocyte activation ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/hiv.12013 |
| Availability: |
https://doi.org/10.1111/hiv.12013; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhiv.12013; https://onlinelibrary.wiley.com/doi/pdf/10.1111/hiv.12013 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.BD12653D |
| Database: |
BASE |