| Title: |
Immune Checkpoint Inhibitor-Related Cytopenias: About 68 Cases from the French Pharmacovigilance Database |
| Authors: |
Martin, Mickaël; Nguyen, Hoan-My; Beuvon, Clément; Bene, Johana; Palassin, Pascale; Atzenhoffer, Marina; Rouby, Franck; Sassier, Marion; Pérault-Pochat, Marie-Christine; Roblot, Pascal; Allouchery, Marion; Puyade, Mathieu |
| Contributors: |
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Centre Régional de Pharmacovigilance du Nord-Pas de Calais, Centre Hospitalier Universitaire de Lille; Département de Pharmacologie Médicale et Toxicologie, Centre Hospitalier Universitaire de Montpellier; Service Hospitalo-Universitaire de Pharmaco-Toxicologie, Hospices Civils de Lyon; CRPV Marseille Provence Corse, service Hospitalo-Universitaire de Pharmacologie Clinique et Pharmacovigilance, Assistance Publique Hôpitaux de Marseille, Marseille, France; Département de Pharmacologie, Centre Hospitalier Universitaire de Caen; SAFT Poitiers; Société des accumulateurs fixes et de traction (SAFT) |
| Source: |
ISSN: 2072-6694. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2022 |
| Collection: |
Hospices Civils de Lyon (HCL): HAL |
| Subject Terms: |
[SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; Data on immune checkpoint inhibitor (ICI)-related cytopenias are scarce. The aim of the study was to further characterize grade ≥ 2 ICI-related cytopenias using the French pharmacovigilance database. Immune thrombocytopenia and autoimmune hemolytic anemia were the most frequently reported ICI-related cytopenias (50.7% and 25.3%, respectively). Nearly half were grade ≥ 4, and 4.4% of patients died from cytopenia-related complications. Using the French pharmacovigilance database, this study provides a comprehensive analysis of ICI-related cytopenias that are rare but potentially life-threatening adverse drug reactions. Early recognition and timely initiation of appropriate treatment are key in their management in clinical practice. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/cancers14205030 |
| Availability: |
https://hal.science/hal-05085751; https://hal.science/hal-05085751v1/document; https://hal.science/hal-05085751v1/file/Martin%20et%20al.%20-%202022%20-%20Immune%20Checkpoint%20Inhibitor-Related%20Cytopenias%20Ab.pdf; https://doi.org/10.3390/cancers14205030 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.BD1DBEB2 |
| Database: |
BASE |