| Title: |
Peripartum outcomes after combined myo-inositol, probiotics, micronutrient supplementation from preconception: NiPPeR RCT: the NiPPeR randomized controlled trial |
| Authors: |
Chan, Shiao-Yng; Yong, Hannah E.J.; Chan, Hsin Fang; Barton, Sheila; Galani, Sevasti; Zhang, Han; El-Heis, Sarah; Wong, Jui-Tsung; Ong, Judith; Ebreo, Marilou; Kenealy, Timothy; Nield, Heidi; Baker, Philip N.; Chong, Yap-Seng; Cutfield, Wayne; Godfrey, Keith |
| Publication Year: |
2022 |
| Collection: |
University of Southampton: e-Prints Soton |
| Description: |
Background: evidence that nutritional supplementation before and during pregnancy improves peripartum outcomes is sparse. In the Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health (NiPPeR) trial, we previously reported that a combined myo-inositol, probiotics, and micronutrient supplement started at preconception showed no difference in the primary outcome of gestational glycemia, but did reduce the risk of preterm delivery, preterm prelabor rupture of membranes, and major postpartum hemorrhage. Objective: this study aimed to examine the hypothesis that a reduction in major postpartum hemorrhage following a combined nutritional (myo-inositol, probiotics, and micronutrients) intervention is linked with promotion of labor progress and reduced operative delivery. Study design: this double-blind randomized controlled trial recruited 1729 women from the United Kingdom, Singapore, and New Zealand, aged 18 to 38 years, and planning conception between 2015 and 2017. The effects of the nutritional intervention compared with those of a standard micronutrient supplement (control), taken at preconception and throughout pregnancy, were examined for the secondary outcomes of peripartum events using multinomial, Poisson, and linear regression adjusting for site, ethnicity, and important covariates. Results: of the women who conceived and progressed beyond 24 weeks’ gestation with a singleton pregnancy (n=589), 583 (99%) provided peripartum data. Between women in the intervention (n=293) and control (n=290) groups, there were no differences in rates of labor induction, oxytocin augmentation during labor, instrumental delivery, perineal trauma, and intrapartum cesarean delivery. Although duration of the first stage of labor was similar, the second-stage duration was 20% shorter in the intervention than in the control group (adjusted mean difference, −12.0 [95% confidence interval, −22.2 to −1.2] minutes; P=.029), accompanied by a reduction in operative delivery ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.soton.ac.uk/469510/1/NiPPeR_peripartum_AJOG_MFM_blinded_submitted_clean.docx; Chan, Shiao-Yng, Yong, Hannah E.J. and Chan, Hsin Fang , NiPPeR Study Group (2022) Peripartum outcomes after combined myo-inositol, probiotics, micronutrient supplementation from preconception: NiPPeR RCT: the NiPPeR randomized controlled trial. American Journal of Obstetrics and Gynecology, 4 (6), [100714]. (doi:10.1016/j.ajogmf.2022.100714 ). |
| Availability: |
https://eprints.soton.ac.uk/469510/; https://eprints.soton.ac.uk/469510/1/NiPPeR_peripartum_AJOG_MFM_blinded_submitted_clean.docx |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.BD369EDC |
| Database: |
BASE |