| Title: |
Barriers and Advances in Kidney Preservation |
| Authors: |
Steichen, C.; Giraud, S.; Bon, D.; Barrou, B.; Badet, L.; Salame, E.; Kerforne, T.; Allain, G.; Roumy, J.; Jayle, C.; Hannaert, Patrick; Hauet, T.; Thuillier, Raphaël |
| Contributors: |
Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques U 1082 (IRTOMIT Poitiers ); Université de Poitiers = University of Poitiers (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de Biochimie CHU Poitiers; Pôle Biospharm (biologie pharmacie santé publique) CHU de Poitiers = Biology, Pharmacy, Public Health Department Poitiers University Hospital (Pôle Biospharm CHU Poitiers ); Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie )-Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Département d'Anesthésie et Réanimation Chirurgicale Poitiers; Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Service de chirurgie cardiothoracique CHU Poitiers; MOPICT – MOdélisation Préclinique, Innovation Chirurgicale et Technologique Plateforme labellisée IBiSA, tutelle INRA (MOPICT); Institut National de la Recherche Agronomique (INRA); Fédération Hospitalo-universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT); Université de Poitiers = University of Poitiers (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Poitiers = University of Poitiers (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT); CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST); Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST); Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie )-Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation (IPPRITT); Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Transplantation, Immunologie, Inflammation Tours (T2i); Université de Tours (UT)-Université de Tours (UT) |
| Source: |
ISSN: 2314-6133. |
| Publisher Information: |
CCSD; Hindawi Publishing Corporation |
| Publication Year: |
2018 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
MESH: Animals; MESH: Humans; MESH: Practice Guidelines as Topic; MESH: Reperfusion Injury / metabolism; MESH: Reperfusion Injury / pathology; MESH: Reperfusion Injury / prevention & control; MESH: Kidney Transplantation; MESH: Kidney; MESH: Organ Preservation / adverse effects; MESH: Organ Preservation / methods; MESH: Perfusion / adverse effects; MESH: Perfusion / methods; [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences; [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]; [SDV.IB]Life Sciences [q-bio]/Bioengineering |
| Description: |
International audience ; Despite the fact that a significant fraction of kidney graft dysfunctions observed after transplantation is due to ischemia-reperfusion injuries, there is still no clear consensus regarding optimal kidney preservation strategy. This stems directly from the fact that as of yet, the mechanisms underlying ischemia-reperfusion injury are poorly defined, and the role of each preservation parameter is not clearly outlined. In the meantime, as donor demography changes, organ quality is decreasing which directly increases the rate of poor outcome. This situation has an impact on clinical guidelines and impedes their possible harmonization in the transplant community, which has to move towards changing organ preservation paradigms: new concepts must emerge and the definition of a new range of adapted preservation method is of paramount importance. This review presents existing barriers in transplantation (e.g., temperature adjustment and adequate protocol, interest for oxygen addition during preservation, and clear procedure for organ perfusion during machine preservation), discusses the development of novel strategies to overcome them, and exposes the importance of identifying reliable biomarkers to monitor graft quality and predict short and long-term outcomes. Finally, perspectives in therapeutic strategies will also be presented, such as those based on stem cells and their derivatives and innovative models on which they would need to be properly tested. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/30643824; PUBMED: 30643824; PUBMEDCENTRAL: PMC6311271 |
| DOI: |
10.1155/2018/9206257 |
| Availability: |
https://hal.science/hal-02346840; https://hal.science/hal-02346840v1/document; https://hal.science/hal-02346840v1/file/Barriers%20and%20Advances%20in%20Kidney%20Preservation.pdf; https://doi.org/10.1155/2018/9206257 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.BD644E15 |
| Database: |
BASE |