| Title: |
Who Benefits Most from Advanced Hybrid Closed Loop Therapy in Pregnancy Across Different Subgroups: A Secondary Analysis of the Randomized Controlled CRISTAL Trial |
| Authors: |
Geerts, Ina; Beunen, Kaat; Peeters, Mart; Wilder, Nancy Van; Ballaux, Dominique; Vanhaverbeke, Gerd; Taes, Youri; Aers, Xavier-Philippe; Nobels, Frank; Van Huffel, Liesbeth; Marlier, Joke; Lee, Dahae; Cuypers, Joke; Preumont, Vanessa; Siegelaar, Sarah E.; Painter, Rebecca C.; Laenen, Annouschka; Gillard, Pieter; Mathieu, Chantal; Benhalima, Katrien |
| Source: |
ISSN:1520-9156 ; ISSN:1557-8593 ; Diabetes Technology & Therapeutics, vol. 28 (3), (253-263. |
| Publisher Information: |
Mary Ann Liebert |
| Publication Year: |
2026 |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Endocrinology & Metabolism; advanced hybrid closed loop system; artificial pancreas; automated insulin delivery; diabetes in pregnancy; glycemic management; technology and diabetes; type 1 diabetes; TYPE-1; Humans; Female; Pregnancy; Adult; Diabetes Mellitus; Type 1; Hypoglycemic Agents; Insulin Infusion Systems; Insulin; Pregnancy in Diabetics; Blood Glucose; Glycated Hemoglobin; Glycemic Control; Blood Glucose Self-Monitoring; Treatment Outcome; 1103 Clinical Sciences; 1116 Medical Physiology; 3202 Clinical sciences |
| Description: |
OBJECTIVE: The CRISTAL trial indicated that advanced hybrid closed loop (AHCL) therapy with MiniMed™ 780G in type 1 diabetes pregnancy did not improve time in range (TIRp) compared with standard insulin therapy (SoC), but improved TIRp overnight and reduced time below range (TBRp). We aimed to evaluate the effect of AHCL therapy across different subgroups. RESEARCH DESIGN AND METHODS: This secondary analysis of the CRISTAL randomized controlled trial compared glycemic outcomes (TIRp, TIRp overnight, TBRp, and TBRp overnight) averaged over the antenatal period (14-, 20-, 26-, and 33-weeks' gestation) between the AHCL and SoC groups, within subgroups defined by baseline characteristics. RESULTS: In women with baseline HbA1c |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: |
English |
| Relation: |
https://lirias.kuleuven.be/handle/20.500.12942/774107; https://doi.org/10.1177/15209156251379505; https://pubmed.ncbi.nlm.nih.gov/40985127 |
| DOI: |
10.1177/15209156251379505 |
| Availability: |
https://lirias.kuleuven.be/handle/20.500.12942/774107; https://hdl.handle.net/20.500.12942/774107; https://lirias.kuleuven.be/retrieve/3cf2a4e6-f570-4c6b-9298-0749053eac3b; https://doi.org/10.1177/15209156251379505; https://pubmed.ncbi.nlm.nih.gov/40985127 |
| Rights: |
info:eu-repo/semantics/openAccess ; public |
| Accession Number: |
edsbas.BD855EF7 |
| Database: |
BASE |