| Title: |
A prospective, case-control study on the lipid profile and the cardiovascular risk of menopausal women on oestrogen plus progestogen therapy in a northern Italy province. |
| Authors: |
Patrelli TS; Franchi L; Berretta R; Pedrazzi G; Volpi L; Lukanovic A; Zanni GC; Modena AB; GIZZO, SALVATORE |
| Contributors: |
Patrelli, T; Gizzo, Salvatore; Franchi, L; Berretta, R; Pedrazzi, G; Volpi, L; Lukanovic, A; Zanni, Gc; Modena, Ab |
| Publication Year: |
2013 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Description: |
PURPOSE: To evaluate the effects of oestrogen plus progestogen therapy (EPT) on the lipid metabolism of menopausal patients. METHODS: We conducted a prospective study on 223 patients with clinical and blood chemistry diagnosis of menopause, who were eligible for hormone therapy and a follow-up period lasting at least 5 years. We selected a control group. Patients attended annual or 6-monthly visits for the duration of the 5-year follow-up period. For each patient, total-cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride values were considered at the first visit and after 5 years. We compared these values of the above parameters in relation to time and EPT and the repercussions that the presence/absence of replacement therapy had in terms of lipid profile alteration between the groups studied. RESULTS: Of the 223 patients eligible for enrolment, 178 made up the study group (EPT Group) and 45 made up the control cohort (N-EPT-Group). At the first visit, median value was (EPT-Group vs. N-EPT-Group): cholesterol was 240 versus 226 mg/dL, LDL-cholesterol 169 versus 174 mg/dL, HDL-cholesterol 60 mg/dL in both groups, triglyceride 125 versus 92 mg/dL (p:n.s). Five years later, median value was (EPT-Group versus N-EPT-Group): cholesterol 225 versus 236 mg/dL (p < 0.001), LDL-cholesterol 125 versus 184 mg/dL (p < 0.001), HDL-cholesterol 64 versus 68 mg/dL (p:n.s.), triglyceride 72 versus 94 mg/dL (p:n.s.). No adverse effects of EPT were observed. CONCLUSIONS: Thorough risk/benefit assessment, associated with initially low doses and without rigid cutoffs, particularly when started early, EPT can be made a valid means of cardiovascular prevention, specifically because it positively alters the lipid profile of menopausal women. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/23287887; info:eu-repo/semantics/altIdentifier/wos/WOS:000320383500014; volume:288; issue:1; firstpage:91; lastpage:97; numberofpages:7; journal:ARCHIVES OF GYNECOLOGY AND OBSTETRICS; https://hdl.handle.net/11577/3128932 |
| DOI: |
10.1007/s00404-012-2702-y |
| Availability: |
https://hdl.handle.net/11577/3128932; https://doi.org/10.1007/s00404-012-2702-y |
| Accession Number: |
edsbas.BDC918F5 |
| Database: |
BASE |