| Title: |
Long-term efficacy and safety of the microsomal triglyceride transfer protein inhibitor lomitapide in patients with homozygous familial hypercholesterolemia |
| Authors: |
Blom D. J.; Averna M. R.; Meagher E. A.; Toit Theron H. D.; Sirtori C. R.; Hegele R. A.; Shah P. K.; Gaudet D.; Stefanutti C.; Vigna G. B.; Larrey D.; Bloedon L. T.; Foulds P.; Rader D. J.; Cuchel M. |
| Contributors: |
Blom, D. J.; Averna, M. R.; Meagher, E. A.; Toit Theron, H. D.; Sirtori, C. R.; Hegele, R. A.; Shah, P. K.; Gaudet, D.; Stefanutti, C.; Vigna, G. B.; Larrey, D.; Bloedon, L. T.; Foulds, P.; Rader, D. J.; Cuchel, M. |
| Publisher Information: |
Lippincott Williams and Wilkins; TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA |
| Publication Year: |
2017 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
lomitapide; Adult; Anticholesteremic Agent; Benzimidazole; Carrier Protein; Cholesterol; LDL; Female; Human; Hyperlipoproteinemia Type II; Male; Time |
| Description: |
Homozygous familial hypercholesterolemia is a genetic disorder characterized by low-density lipoprotein (LDL)-receptor dysfunction, markedly elevated levels of LDL-cholesterol (LDL-C) and premature atherosclerosis. Patients are often poorly responsive to conventional lipid-lowering therapies that upregulate LDL-receptor expression. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28716835; info:eu-repo/semantics/altIdentifier/wos/WOS:000405575300012; volume:136; issue:3; firstpage:332; lastpage:335; numberofpages:4; journal:CIRCULATION; http://hdl.handle.net/11573/1504576 |
| DOI: |
10.1161/CIRCULATIONAHA.117.028208 |
| Availability: |
http://hdl.handle.net/11573/1504576; https://doi.org/10.1161/CIRCULATIONAHA.117.028208 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.BDCA34DD |
| Database: |
BASE |