Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis
| Title: | Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis |
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| Authors: | Singh, Bhagteshwar; Lant, Suzannah; Cividini, Sofia; Cattrall, Jonathan W S; Goodwin, Lynsey C; Benjamin, Laura; Michael, Benedict D; Khawaja, Ayaz; Matos, Aline de Moura Brasil; Alkeridy, Walid; Pilotto, Andrea; Lahiri, Durjoy; Rawlinson, Rebecca; Mhlanga, Sithembinkosi; Lopez, Evelyn C; Sargent, Brendan F; Somasundaran, Anushri; Tamborska, Arina; Webb, Glynn; Younas, Komal; Al Sami, Yaqub; Babu, Heavenna; Banks, Tristan; Cavallieri, Francesco; Cohen, Matthew; Davies, Emma; Dhar, Shalley; Fajardo Modol, Anna; Farooq, Hamzah; Harte, Jeffrey; Hey, Samuel; Joseph, Albert; Karthikappallil, Dileep; Kassahun, Daniel; Lipunga, Gareth; Mason, Rachel; Minton, Thomas; Mond, Gabrielle; Poxon, Joseph; Rabas, Sophie; Soothill, Germander; Zedde, Marialuisa; Yenkoyan, Konstantin; Brew, Bruce; Contini, Erika; Cysique, Lucette; Zhang, Xin; Maggi, Pietro; van Pesch, Vincent; Lechien, Jérome; Saussez, Sven; Heyse, Alex; Brito Ferreira, Maria Lúcia; Soares, Cristiane N; Elicer, Isabel; Eugenín-von Bernhardi, Laura; Ñancupil Reyes, Waleng; Yin, Rong; Azab, Mohammed A; Abd-Allah, Foad; Elkady, Ahmed; Escalard, Simon; Corvol, Jean-Christophe; Delorme, Cécile; Tattevin, Pierre; Bigaut, Kévin; Lorenz, Norbert; Hornuss, Daniel; Hosp, Jonas; Rieg, Siegbert; Wagner, Dirk; Knier, Benjamin; Lingor, Paul; Winkler, Andrea Sylvia; Sharifi-Razavi, Athena; Moein, Shima T; SeyedAlinaghi, SeyedAhmad; JamaliMoghadamSiahkali, Saeidreza; Morassi, Mauro; Padovani, Alessandro; Giunta, Marcello; Libri, Ilenia; Beretta, Simone; Ravaglia, Sabrina; Foschi, Matteo; Calabresi, Paolo; Primiano, Guido; Servidei, Serenella; Biagio Mercuri, Nicola; Liguori, Claudio; Pierantozzi, Mariangela; Sarmati, Loredana; Boso, Federica; Garazzino, Silvia; Mariotto, Sara; Patrick, Kimani N; Costache, Oana; Pincherle, Alexander; Klok, Frederikus A; Meza, Roger; Cabreira, Verónica; Valdoleiros, Sofia R; Oliveira, Vanessa; Kaimovsky, Igor; Guekht, Alla; Koh, Jasmine; Fernández Díaz, Eva; Barrios-López, José María; Guijarro-Castro, Cristina; Beltrán-Corbellini, Álvaro; Martínez-Poles, Javier; Diezma-Martín, Alba María; Morales-Casado, Maria Isabel; García García, Sergio; Breville, Gautier; Coen, Matteo; Uginet, Marjolaine; Bernard-Valnet, Raphaël; Du Pasquier, Renaud; Kaya, Yildiz; Abdelnour, Loay H; Rice, Claire; Morrison, Hamish; Defres, Sylviane; Huda, Saif; Enright, Noelle; Hassell, Jane; D'Anna, Lucio; Benger, Matthew; Sztriha, Laszlo; Raith, Eamon; Chinthapalli, Krishna; Nortley, Ross; Paterson, Ross; Chandratheva, Arvind; Werring, David J; Dervisevic, Samir; Harkness, Kirsty; Pinto, Ashwin; Jillella, Dinesh; Beach, Scott; Gunasekaran, Kulothungan; Rocha Ferreira Da Silva, Ivan; Nalleballe, Krishna; Santoro, Jonathan; Scullen, Tyler; Kahn, Lora; Kim, Carla Y; Thakur, Kiran T; Jain, Rajan; Umapathi, Thirugnanam; Nicholson, Timothy R; Sejvar, James J; Hodel, Eva Maria; Tudur Smith, Catrin; Solomon, Tom |
| Contributors: | Singh, Bhagteshwar; Lant, Suzannah; Cividini, Sofia; Cattrall, Jonathan W S; Goodwin, Lynsey C; Benjamin, Laura; Michael, Benedict D; Khawaja, Ayaz; Matos, Aline de Moura Brasil; Alkeridy, Walid; Pilotto, Andrea; Lahiri, Durjoy; Rawlinson, Rebecca; Mhlanga, Sithembinkosi; Lopez, Evelyn C; Sargent, Brendan F; Somasundaran, Anushri; Tamborska, Arina; Webb, Glynn; Younas, Komal; Al Sami, Yaqub; Babu, Heavenna; Banks, Tristan; Cavallieri, Francesco; Cohen, Matthew; Davies, Emma; Dhar, Shalley; Fajardo Modol, Anna; Farooq, Hamzah; Harte, Jeffrey; Hey, Samuel; Joseph, Albert; Karthikappallil, Dileep; Kassahun, Daniel; Lipunga, Gareth; Mason, Rachel; Minton, Thoma; Mond, Gabrielle; Poxon, Joseph; Rabas, Sophie; Soothill, Germander; Zedde, Marialuisa; Yenkoyan, Konstantin; Brew, Bruce; Contini, Erika; Cysique, Lucette; Zhang, Xin; Maggi, Pietro; van Pesch, Vincent; Lechien, Jérome; Saussez, Sven; Heyse, Alex; Brito Ferreira, Maria Lúcia; Soares, Cristiane N; Elicer, Isabel; Eugenín-von Bernhardi, Laura; Ñancupil Reyes, Waleng; Yin, Rong; Azab, Mohammed A; Abd-Allah, Foad; Elkady, Ahmed; Escalard, Simon; Corvol, Jean-Christophe; Delorme, Cécile; Tattevin, Pierre; Bigaut, Kévin; Lorenz, Norbert; Hornuss, Daniel; Hosp, Jona; Rieg, Siegbert; Wagner, Dirk; Knier, Benjamin; Lingor, Paul; Winkler, Andrea Sylvia; Sharifi-Razavi, Athena; Moein, Shima T; Seyedalinaghi, Seyedahmad; Jamalimoghadamsiahkali, Saeidreza; Morassi, Mauro; Padovani, Alessandro; Giunta, Marcello; Libri, Ilenia; Beretta, Simone; Ravaglia, Sabrina; Foschi, Matteo; Calabresi, Paolo; Primiano, Guido; Servidei, Serenella; Biagio Mercuri, Nicola; Liguori, Claudio; Pierantozzi, Mariangela; Sarmati, Loredana; Boso, Federica; Garazzino, Silvia; Mariotto, Sara; Patrick, Kimani N; Costache, Oana; Pincherle, Alexander; Klok, Frederikus A; Meza, Roger |
| Publication Year: | 2022 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: | COVID-19; Hospitals; Encephalitis; Metaanalysis; Dementia; Cerebrospinal fluid; Stroke; Medical risk factors |
| Description: | Background: Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. Methods: We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. Results: We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67-82]), than encephalopathy (54% [42-65]). Intensive care use was high (38% [35-41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27-32]. The hazard of death was comparatively lower for patients in the WHO European region. Interpretation: Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and ... |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35653330; info:eu-repo/semantics/altIdentifier/wos/WOS:000843619700020; volume:17; issue:6; firstpage:e0263595; lastpage:1; numberofpages:26; journal:PLOS ONE; https://hdl.handle.net/11562/1067303; https://doi.org/10.1371/journal.pone.0263595 |
| DOI: | 10.1371/journal.pone.0263595 |
| Availability: | https://hdl.handle.net/11562/1067303; https://doi.org/10.1371/journal.pone.0263595 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Dominio pubblico ; license uri:http://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: | edsbas.BDEF707A |
| Database: | BASE |