| Title: |
Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project |
| Authors: |
Larson, LM; Namaste, SM; Williams, AM; Engle-Stone, R; Addo, OY; Suchdev, PS; Wirth, JP; Temple, V; Serdula, M; Northrop-Clewes, CA |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2017 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Background: The accurate estimation of the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions. Retinol-binding protein (RBP) is often used in population surveys to measure vitamin A status, but its interpretation is challenging in settings where inflammation is common because RBP concentrations decrease during the acute-phase response.Objectives: We aimed to assess the relation between RBP concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and to investigate adjustment algorithms to account for these effects.Design: Cross-sectional data from 8 surveys for PSC (n = 8803) and 4 surveys for WRA (n = 4191) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and combined with the use of a meta-analysis. Several approaches were explored to adjust RBP concentrations in PSC in inflammation and malaria settings as follows: 1) the exclusion of subjects with C-reactive protein (CRP) concentrations >5 mg/L or α-1-acid glycoprotein (AGP) concentrations >1 g/L, 2) the application of arithmetic correction factors, and 3) the use of a regression correction approach. The impact of adjustment on the estimated prevalence of VAD (defined as |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0002-9165 |
| Relation: |
https://hdl.handle.net/11343/271326 |
| Availability: |
https://hdl.handle.net/11343/271326 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.BDEFC5D2 |
| Database: |
BASE |