| Title: |
The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy |
| Authors: |
Pang, Michelle D; Bastings, Jacco J A J; Op den Kamp-Bruls, Yvonne M H; Harrold, Joanne A; Kjølbæk, Louise; Halford, Jason C G; Adam, Tanja C M; Raben, Anne; Schrauwen-Hinderling, Vera B; Goossens, Gijs H; Blaak, Ellen E |
| Source: |
Pang , M D , Bastings , J J A J , Op den Kamp-Bruls , Y M H , Harrold , J A , Kjølbæk , L , Halford , J C G , Adam , T C M , Raben , A , Schrauwen-Hinderling , V B , Goossens , G H & Blaak , E E 2023 , ' The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy ' , Obesity , vol. 31 , no. 7 , pp. 1745-1754 . https://doi.org/10.1002/oby.23773 |
| Publication Year: |
2023 |
| Collection: |
University of Copenhagen: Research / Forskning ved Københavns Universitet |
| Subject Terms: |
Weight loss; Insulin sensitivity; Intrahepatic lipid; Overweight; Obesity; /dk/atira/pure/core/keywords/TheFacultyOfScience; name=Faculty of Science |
| Description: |
Objective: This study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. Methods: In this secondary analysis of the European SWEET project, 50 adults (age 18–65 years) with overweight or obesity (BMI ≥ 25 kg/m 2 ) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test). Results: The LED reduced body weight ( p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI ( p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI ( r = 0.402, p = 0.025). Conclusions: Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| DOI: |
10.1002/oby.23773 |
| Availability: |
https://researchprofiles.ku.dk/da/publications/85220b65-e32d-4763-a68a-0ced796c2e35; https://doi.org/10.1002/oby.23773; https://curis.ku.dk/ws/files/361378849/Pang_et_al_Obesity_2023_Vol_31_7_1745_1754.pdf |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.BE0E1A40 |
| Database: |
BASE |