| Title: |
Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study): a prospective, international collaborative cohort study |
| Authors: |
Neves-Marques, Claudia; Abulazayem, Mohamed; Wong, Geoffrey Yuet Mun; Maldonado, Ricardo David; Viswanath, Yirupaiahgari; Boddy, Alex; Donohoe, Claire; Scarano, Juan Pablo; Martinino, Alessandro; Aamery, Amaar; Abdulkhakimov, Nuriddin; Abuobaida, Essam Eldien; Aday, Ulaş; Al-Shami, Khayry; Alhajami, Faris; Almeida, Ana; Almoshantaf, Mohammad Badr; Ahmed, Hassan; Andrada, Martín; Anwer, Abdul Wahid; Awad, Ahmed K.; Baili, Efstratia; Baraket, Oussama; Barbosa, José; Baker, Cara; Bakri, Ashraf; Boras, Zdenko; Caiado, André; Cayirci, Can; Calini, Giacomo; Cianci, Pasquale; Cinal, Esin; Chouliaras, Christos; Colak, Elif; Correia, Maria Teresa; Costeira, Beatriz; Davletshina, Viktoria; D'Acapito, Fabrizio; Donmez, Turgut; Drozdov, Evgeniy; Ercolani, Giorgio; Erdene, Sarnai; Erginöz, Ergin; Ferreira, Samantha Rocha; Fragoso, Marta; Framarini, Massimo; Galandarova, Aysuna; Genser, Laurent; Gorohov, Ilya; Grosek, Jan; Guerrero, Silvia; Hasırcı, Ismail; Ibrahimli, Arturan; Ithurralde-Argerich, Javier; Karabulut, Mehmet; Kinoshita, Takahiro; Khalid, Ibtissam Bin; Khan, Khurram; Khattak, Shahid; Khomyakov, Vladimir; Krawczyk, Wiktor; Khamees, Almu'atasim; Kostrygin, Alexander; Košir, Jurij; Lorenc, Zbigniew; Milhomem, Jorge; Marom, Gadi; Melo, Ana; Menasria, Abdelkader; Meric, Serhat; Mulita, Francesk; Muratore, Andrea; Omarov, Taryel; Palomba, Giuseppe; Paul, Negine; Pathak, Akshant; Pavone, Giovanna; Pavlov, Rostislav; Pinillla, Raul; Rasheed, Omeed; Remini, Anouar; Ryabov, Andrey; Samadov, Elgun; Samarasam, Inian; Sandag, Erdene; Santos, Jorge; Sanchez, Elio; Saroglu, Azize; Schizas, Dimitrios; Serralheiro, Pedro Azevedo; Simsek, Oguzhan; Sobolev, Dmitry; Souadka, Amine; de Sousa, José Vieira; Sousa, Fabiana; Suer, Muhammed; Surendran, Suraj; Syllaios, Athanasios; Syed, Aamir Ali; Terajima, Daiki; Tokocin, Merve; Triantafyllou, Tania; Uludağ, Server; Uprak, Tevfik; Vaz, Susan; Vecchiato, Massimo; Verras, Georgios Ioannis; Veroux, Massimiliano; Voon, Kelvin; Vovin, Kirill; Yacob, Myla; Walędziak, Maciej; Zacharenko, Alexander; Zahara, Fatima Tu; Singhal, Rishi; Mahawar, Kamal; null, null; Abbas, Ahmed M.; Abbassi, Imed; Abdelhamid, Ibrahim; Abente, Federico; Abid, Haider; Abouleid, Ayman; Acín-Gándara, Hans Débora; Adeyeye, Ademola A.; Ads, Alaa Mohamed; Akkapulu, Nezih; Aktokmakyan, Talar Vartanoglu; Aksenov, Sergei; Agbonrofo, Peter Ikponmwosa; Al-Dahdouh, Mosheer S.; Allahverdiyeva, Nigar; Al-Shami, Manar; Ali, Zaid Al-Sheikh; Al-Sallal, Rawan Mohammed; Alsheikh, Ahmad Malek; Al-Naggar, Hamza; Allawgalli, Aiman; Al-Issawi, Subhi Zahi; Al-Tahayneh, Sief-Addeen; Ammendola, Michele; Ammar, Ahmed Y.; Amrani, Laila; Annecchiarico, Mario; Anestiadou, Elissavet; Antozzi, Luciano; Aprea, Giovanni; Argenio, Giulio; Arikan, Akif Enes; Askari, Alan; Assisi, Alberto; Atiah, Nora Ra'ed; Awad, Selmy S.; Ayed, Karim; Arslan, Kemal; Bachet, Jean-Baptiste; Balcazar, Juan; Bala, Vignesh; De Leon Ballesteros, Guillermo Ponce; Bali, Christina D.; Balla, Andrea; Barbosa, Laura E. R.; Bartolomeo, Stefano; Basile, Raffaele; Bayramov, Nurur; Bhasker, Aparna Govil; Bello, Usman M.; Belkhadir, Zakaria Houssain; Bendemagal, Mahesh; Benkabbou, Amine; Bera, Solomon; Bernardes, Antonio Jose; Bernardo, Patrícia; Bianco, Federica; Bitsianis, Stefanos; Bolota, Joana S.; Bonomi, Alessandro; Borges, Nuno; Bozkır, Haktan Övül; Brahim, El Ahmadi; Bresadola, Vittorio; Bruna, Marcos; Bueno, Andrew D.; Busnelli, Virginia Cano; Bulathsinhela, Rasika; Cabral, Francisco; Calabrò, Marcello; Capkinoglu, Emir; Capuano, Marianna; Campo, Constantino Fondevila; Carrabetta, Salvatore; Caruana, Clifford; Casaca, Rui; Del Castillo-Díez, Federico; Catena, Fausto; Centonze, Danilo; Chaika, Anna; Charalabopoulos, Alexandros; Chokshi, Aishwarya; Chong, Lynn; Cotsoglou, Christian; Chircop, Daniel M.; Chowdhury, Sharfuddin; Chumbinho, Beatriz; Chandran, Sudhakar; Chiarella, Leonardo Luca; Conversano, Ivana; Costa, Paulo M.; Chokkalingam, Gangalakshmi; Cuevas, Liliana; Currò, Jan Giuseppe; Chadli, Noureddine; Ćuk, Vladica V.; Dapri, Giovanni; Dardanov, Dragomir; Dash, Anuj; Dimofte, Gabriel Mihail; Davies, Andrew R.; Diaz, Angel; Dogjani, Agron; Dülgeroğlu, Onur; Duro, Agustin; Dulac, Anne Sophie; Eid, Mohammed Hisham; Elghadban, Hosam; Elnga, Nagm Eldin Abu; Elfawal, Mohamad; Eric, Hazebroek; Evola, Giuseppe; Fahmi, Sarah K.; Filippelli, Alice; Fishman, Yuri; Fırat, Muratcan; Forshaw, Matthew; Fouzdar, Aakash; Frattini, Francesco; Frazão, Joana R.; Gall, Lewis S.; Garcia, Luca Casingena; Ganesan, Senthilkumar; Gerogiannis, Ioannis; Ghalloussi, Mohamed Hedi; Goodman, Elliot; Gossage, James A.; Granieri, Stefano; Gupta, Amit; Gunawardene, Ashok R.; Gupta, Rahul; Hamid, Hytham; Hammadieh, Abdul Rahman; Hammerschlag, Joshua N.; Henao, Francisco J.; Herrera, Rufino Eduardo; Hii, Michael W.; Hosny, Samir; Hong, Joshua; Intzes, Nikolaos; Ioannidis, Orestis; Irowa, Omorodion Omoruyi; Ivanov, Ivaylo; Jamal, Rawia; Jambulingam, Periyathambi; Jayyab, Mustafa A. Abu; Julianov, Alexander; Kalinina, Tatyana S.; Kamalov, Aziz; Kayali, Ahmad Amir H.; Kayyal, Mohd; Kumar, Vijay; Kaur, Mandeep; Keen, Askar J.; Kelly, Mark; Kermansaravi, Mohammad; Kim, Guowei; Kisielewski, Michal; Klib, Mohamad; Khanduri, Archana; Khan, Mansoor; Khaw, Cheng Jing; Khlouf, Malak Khaled; Koreshkova, Karina; Kovačević, Bojan M.; Lages, Patricia M. P.; Lahnaoui, Oumaima; Lai, Larry Weng Hong; Laranjo, Pedro; Lasithiotakis, Konstantinos; Lazaros, Lazarou; Lepiane, Pasquale; Lianos, Georgios D.; Licciardello, Alessio; Da Lio, Corrado; Liu, Gordon; Lunca, Sorinel; Luzzi, Andrea-Pierre; Macchini, Daniele; Mancin, Annalisa; Marcos, Mário S.; Martins, Rita V.; Mahendran, Alexander; Majbar, Mohammed Anass; Makurina, Marina; Matias, Rosa J.; Massadi, Mustafa Sabri; Masri, Ruqaya; Mbonicura, Jean; Mesquita, Isabel M.; Milentijević, Milica A.; Miza, Migena; Moniz, Lourenço; Morgagni, Paolo; Moser, Federico; Mohammed, Adnan; Mohsine, Raouf; Monteiro, Cecília; Mondi, Isabella; Morezzi, Daniele; Musina, Ana-Maria; Nadeesh, Areej Esam; Nagliati, Carlo; Naranjo, Eddy Lincango; Naser, Ayman Ibrahim; Nashidengo, Pueya; Neimark, Aleksandr; Negoi, Ionut; Nesargikar, Prabhu N.; Nessi, Chiara; Van Nood, Elena Herranz; Obeide, Lucio Rircardo; Olmi, Stefano; Oliveira, Joana Ip; Onofre, Susana S.; Oriakhi, Steve-Nation Nehiweze; Ouadii, Mouaqit; Özçelik, Mehmet Faik; Özdemir, Zeynep; Ozmen, Mahir; De Palma, Giovanni Domenico; Pandey, Anshuman; Palmieri, Hugo; Patrício, Bernardo L.; Peksen, Caghan; Petkov, Plamen; Pinotti, Enrico; Pogosyan, Gegam; Pouwels, Sjaak; Pupo, Alexandra; Qayum, Aisha; Quan, Carlos Coello; Ramos, Paulo; Rajput, Deepak; Rajan, Shiv; Raza, Muhammad Shahan; Read, Matthew; Reis, Sofia; Rey, Samuel E.; Ribeiro, João G.; Righetti, Carolina; Roata, Cristian-Ene; Romairone, Emanuele; Roshan, Homayoon; Rosner, Laura; Ruiz-Úcar, Elena; Santangelo, Antonio; Santos, Catarina Rolo; Said, Amira; Şahin, Alpaslan; Sakran, Nasser; Salimzyanov, Kamil; Saraceno, Federica; Sarda, Hitesh; Savas, Osman Anil; Sawaftah, Marah Ahmad; Sawaftah, Mohammad Ahmad; Sawaftah, Khaled Ahmad; Shafiq, Ahsan; Shabbir, Azhar; Shariff, Amir; Signorini, Franco; Sidiropoulos, Theodoros A.; Silva, Silvia; So, Jimmy Bok Yan; De Sousa, João Pinto; Soares, Paulo A.; Solaini, Leonardo; Spartalis, Eleftherios; Spartalis, Michael; Stratoulias, Konstantinos; Subasinghe, Duminda; Subbarayan, Shankar; Sumer, Aziz; Sulo, Fjorenta; Symeonidis, Savvas; Sylvester, Kimutai Ronoh; Taha, Safwan; Takeda, Flavio Roberto; Tampakis, Athanasios; Tartaglia, Nicola; Temerik, Abdallah R.; Tewari, Nilanjana; Tidjane, Anisse; Tilioua, Omar; Theodoropoulos, Charalampos; Tomažič, Aleš; Toro-Huamanchumo, Carlos; Triantafyllou, Alexandra; Tsikritzakis, Ioannis; Tyseer, Tyseer Median; Tuminello, Fabio; Uccelli, Fara; Uccelli, Matteo; Ulutaş, Mehmet Eşref; Uras, Cihan; Utkina, Anna; Vailas, Michail; Vaillant, Jean Christophe; Valenzuela, José I.; Vallicelli, Carlo; Velenciuc, Natalia; Verdi, Daunia; Vesga, Marlon A.; Vieira, João S.; Vlahovic, Nakul Viswanath Ivan; Wanjara, Samuel; Wazir, Ishaan; Wei, Zhuoqi; Wietzycoski, Cacio; Wysocki, Wojciech M.; Yacoub, Bara' Sami; Yang, Wah; Yassin, Raghad Yousef; Yılmaz, Ayşegül; Yordanov, David; Zengin, Kağan; Zucchini, Valentina; Zuluaga, Mauricio |
| Contributors: |
Neves-Marques, Claudia; Abulazayem, Mohamed; Wong, Geoffrey Yuet Mun; Maldonado, Ricardo David; Viswanath, Yirupaiahgari; Boddy, Alex; Donohoe, Claire; Scarano, Juan Pablo; Martinino, Alessandro; Aamery, Amaar; Abdulkhakimov, Nuriddin; Abuobaida, Essam Eldien; Aday, Ulaş; Al-Shami, Khayry; Alhajami, Fari; Almeida, Ana; Almoshantaf, Mohammad Badr; Ahmed, Hassan; Andrada, Martín; Anwer, Abdul Wahid; Awad, Ahmed K.; Baili, Efstratia; Baraket, Oussama; Barbosa, José; Baker, Cara; Bakri, Ashraf; Boras, Zdenko; Caiado, André; Cayirci, Can; Calini, Giacomo; Cianci, Pasquale; Cinal, Esin; Chouliaras, Christo; Colak, Elif; Correia, Maria Teresa; Costeira, Beatriz; Davletshina, Viktoria; D'Acapito, Fabrizio; Donmez, Turgut; Drozdov, Evgeniy; Ercolani, Giorgio; Erdene, Sarnai; Erginöz, Ergin; Ferreira, Samantha Rocha; Fragoso, Marta; Framarini, Massimo; Galandarova, Aysuna; Genser, Laurent; Gorohov, Ilya; Grosek, Jan; Guerrero, Silvia; Hasırcı, Ismail; Ibrahimli, Arturan; Ithurralde-Argerich, Javier; Karabulut, Mehmet; Kinoshita, Takahiro; Khalid, Ibtissam Bin; Khan, Khurram; Khattak, Shahid; Khomyakov, Vladimir; Krawczyk, Wiktor; Khamees, Almu'Atasim; Kostrygin, Alexander; Košir, Jurij; Lorenc, Zbigniew; Milhomem, Jorge; Marom, Gadi; Melo, Ana; Menasria, Abdelkader; Meric, Serhat; Mulita, Francesk; Muratore, Andrea; Omarov, Taryel; Palomba, Giuseppe; Paul, Negine; Pathak, Akshant; Pavone, Giovanna; Pavlov, Rostislav; Pinillla, Raul; Rasheed, Omeed; Remini, Anouar; Ryabov, Andrey; Samadov, Elgun; Samarasam, Inian; Sandag, Erdene; Santos, Jorge; Sanchez, Elio; Saroglu, Azize; Schizas, Dimitrio; Serralheiro, Pedro Azevedo; Simsek, Oguzhan; Sobolev, Dmitry; Souadka, Amine; De Sousa, José Vieira; Sousa, Fabiana; Suer, Muhammed; Surendran, Suraj; Syllaios, Athanasio; Syed, Aamir Ali; Terajima, Daiki |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
Gastric cancer · Elective surgery · Morbidity and mortality · 90-Day postoperative outcomes · Multinational audit · Surgical Complications · Anastomotic leaks · Patient safety |
| Description: |
Background Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes among patients undergoing elective gastric cancer surgery, as in the GASTRODATA Registry, and to identify associated risk factors. Methods We conducted an international prospective study on patients aged ≥ 18 years undergoing elective surgery for gastric cancer with curative intent from January 4 to September 30, 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression were used to identify variables associated with the 90-day outcome. Results 380 collaborators from 47 countries submitted data on 1538 patients. Median age was 65 years (IQR: 19–94), and 58.5% were males. 90-day morbidity and mortality rates were 38.2% (n = 587) and 2.9% (n = 45), respectively. Pre-operative higher Charlson Comorbidity Index, higher ASA score, pre-operative weight loss > 10%, positive specimen margin, and post-operative pathological IV staging (p value < 0.05) were significantly associated with clinically relevant complications and mortality. Conclusion Elective gastric cancer surgery has a 90-day morbidity of 38.2% and a 90-day mortality of 2.9% globally. This study provided the most comprehensive international 90-day prospective data to date regarding gastric cancer surgery. Several factors associated with higher morbidity were identified, highlighting the importance of a unified language on surgical morbidity, prehabilitation, and ongoing audits to enhance patient outcomes. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41236666; info:eu-repo/semantics/altIdentifier/wos/WOS:001616338100001; volume:411; issue:1; firstpage:1; lastpage:16; numberofpages:16; journal:LANGENBECK'S ARCHIVES OF SURGERY; https://hdl.handle.net/11585/1033390 |
| DOI: |
10.1007/s00423-025-03890-7 |
| Availability: |
https://hdl.handle.net/11585/1033390; https://doi.org/10.1007/s00423-025-03890-7; https://link.springer.com/article/10.1007/s00423-025-03890-7 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY) ; license uri:iris.PUB15 |
| Accession Number: |
edsbas.BE0ECD4 |
| Database: |
BASE |