| Title: |
High-sensitivity cardiac troponin I and frailty: Associations with the frailty index and fried phenotype in older women |
| Authors: |
Pratt, Jedd; Gebre, Abadi K.; Toro-Huamanchumo, Carlos J.; Dent, Elsa; Bozanich, Trent; Lim, Wai E.; Byrnes, Elizabeth; McDonagh, Julee; Ferguson, Caleb; Sale, Craig; Zhu, Kun; Schultz, Carl; Prince, Richard L.; Lewis, Joshua R.; Sim, Marc |
| Source: |
Research outputs 2022 to 2026 |
| Publisher Information: |
Edith Cowan University, Research Online, Perth, Western Australia |
| Publication Year: |
2026 |
| Collection: |
Edith Cowan University (ECU, Australia): Research Online |
| Subject Terms: |
Biomarkers; Cardiovascular disease; Frailty; Public health; Screening; Endocrinology; Diabetes; and Metabolism; Medical Specialties; Medicine and Health Sciences |
| Description: |
Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were associated with frailty in a well-characterized cohort of older women. A total of 1151 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. Frailty was operationalized using a validated frailty index (FI) of cumulative deficits and a modified Fried phenotype. Plasma hs-cTnI were categorized into quartiles. Cross-sectional associations between hs-cTnI quartiles and frailty were assessed using multivariable-adjusted logistic regression models. A total of 235 (20.4%) women were classified as frail using the FI, while 74 (6.4%) were considered frail by Fried's phenotype. In a multivariable-adjusted model, compared to women in the lowest hs-cTnI quartile (Q1), those in Q3 and Q4 had 1.38 (95% CI, 1.00-1.90) and 1.79 (1.20-2.67) greater odds for frailty when classified by the FI. When classified according to Fried's phenotype, women in Q2, Q3, and Q4 had 2.25 (1.10-4.09), 2.64 (1.19-5.21), and 2.44 (1.10-5.33) greater odds for frailty, compared to Q1. Associations remained largely unchanged when further adjusted for daily protein intake or systemic inflammation (lipocalin-2) and restricted to those with subclinical hs-cTnI levels ( |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
unknown |
| DOI: |
10.1093/gerona/glaf235 |
| Availability: |
https://ro.ecu.edu.au/ecuworks2022-2026/7591; https://doi.org/10.1093/gerona/glaf235; https://ro.ecu.edu.au/context/ecuworks2022-2026/article/8591/viewcontent/High_sensitivity_20cardiac_20troponin.pdf |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.BE44C634 |
| Database: |
BASE |