| Title: |
The SIDECAR 2.0 (S-ICD registry in European paediatric and young adult patients with congenital heart defects 2.0) : an analysis of European S-ICD clinical practice and its evolution in paediatric patients |
| Authors: |
Silvetti, Massimo Stefano; Bruyndonckx, Luc; Waldmann, Victor; Gebauer, Roman; Környei, László; Ksiazczyk, Tomasz; Illikova, Vieira; Tavacova, Terezia; Roses-Noguer, Ferran; Kwiatkowska, Joanna; Pazzano, Vincenzo; Wilkin, Marie; Paech, Christian; Fésüs, Gábor; Egorova, Anastasia D.; Wieniawski, Piotr; Rivas-Gandara, Núria; Kempa, Maciej; Battipaglia, Irma; Klehs, Sophia; Chalupka, Michal; Maltret, Alice; Knops, Reinoud E.; Janousek, Jan; Blom, Nico A.; Lovecchio, Mariolina; Valsecchi, Sergio; Drago, Fabrizio |
| Source: |
1099-5129 ; Europace |
| Publication Year: |
2025 |
| Collection: |
IRUA - Institutional Repository van de Universiteit Antwerpen |
| Subject Terms: |
Human medicine |
| Description: |
Aims Subcutaneous implantable cardioverter-defibrillators (S-ICDs) are effective in patients who require protection from sudden cardiac death while avoiding the long-term risks associated with transvenous leads. However, data on their real-world performance in paediatric and young patients remain limited. This study aims to evaluate the safety and efficacy of S-ICDs in a large, multicentre cohort of paediatric and young patients across Europe, with a focus on contemporary implantation practices and clinical outcomes. Methods and results This is an international, multicentre, observational, retrospective registry on S-ICD outcome in paediatric and young adult patients with congenital heart defects (CHD), cardiomyopathies, channelopathies, and idiopathic ventricular fibrillation (IVF). Data were collected on implantation techniques, acute and long-term outcomes, including defibrillation efficacy, inappropriate (IAS) and appropriate shocks, and complications. Follow-up data were analysed to assess device performance and safety. A total of 223 patients (mean age: 15 ± 3 years; 59% male, 53% cardiomyopathies, 18% channelopathies, 15% IVF, 14% CHD) were included. Most patients underwent implantation using an intermuscular (65%) and two-incision technique (88%). Acute defibrillation success was 100%, and no intraoperative complications occurred. The median follow-up was 28 (IQR: 12–55) months. Appropriate shocks were delivered in 41 (18%) patients (26% rate at 5 years). The first shock was effective in 92% of discrete episodes. The IAS and the complication rates were 20% and 5% at 5 years. Older age, intermuscular pocket, and two-incision technique were associated with fewer complications. Conclusion This multicentre S-ICD European registry in paediatric and young patients demonstrated favourable outcomes, low IAS, and complication rates |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/isi/001624860000001 |
| Availability: |
https://hdl.handle.net/10067/2187870151162165141; https://repository.uantwerpen.be/docstore/d:irua:32370 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.BEC14862 |
| Database: |
BASE |