Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry
| Title: | Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry |
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| Authors: | Nettleton, JA; Follis, JL; Ngwa, JS; Smith, CE; Ahmad, Shahzad; Tanaka, T; Wojczynski, MK; Voortman, Trudy; Lemaitre, RN; Kristiansson, K; Nuotio, ML; Houston, DK; Perala, MM; Qi, QB; Sonestedt, E; Manichaikul, A; Kanoni, S; Ganna, A; Mikkila, V; North, KE; Siscovick, DS; Harald, K; McKeown, NM; Johansson, I; Rissanen, H; Liu, YM; Lahti, J; Hu, FB; Bandinelli, S; Rukh, G; Rich, S; Booij, L; Dmitriou, M; Ax, E; Raitakari, O; Mukamal, K; Mannisto, S; Hallmans, G; Jula, A; Ericson, U; Jacobs, DR; van Rooij, FJA; Deloukas, P; Sjogren, P; Kahonen, M; Djousse, L; Perola, M; Barroso, I; Hofman, Bert; Stirrups, K; Viikari, J; Uitterlinden, André; Kalafati, IP; Franco Duran, OH; Mozaffarian, D; Salomaa, V; Borecki, IB; Knekt, P; Kritchevsky, SB; Eriksson, JG; Dedoussis, GV; Qi, L; Ferrucci, L; Orho-Melander, M; Zillikens, M.C.; Ingelsson, E; Lehtimaki, T; Renstrom, F; Cupples, LA; Loos, RJF; Franks, PW |
| Source: | Nettleton, JA, Follis, JL, Ngwa, JS, Smith, CE, Ahmad, S, Tanaka, T, Wojczynski, MK, Voortman, T, Lemaitre, RN, Kristiansson, K, Nuotio, ML, Houston, DK, Perala, MM, Qi, QB, Sonestedt, E, Manichaikul, A, Kanoni, S, Ganna, A, Mikkila, V, North, KE, Siscovick, DS, Harald, K, McKeown, NM, Johansson, I, Rissanen, H, Liu, YM, Lahti, J, Hu, FB, Bandinelli, S, Rukh, G, Rich, S, Booij, L, Dmitriou, M, Ax, E, Raitakari, O, Mukamal, K, Mannisto, S, Hallmans, G, Jula, A, Ericson, U, Jacobs, DR, van Rooij, FJA, Deloukas, P, Sjogren, P, Kahonen, M, Djousse, L, Perola, M, Barroso, I, Hofman, B, .... |
| Publication Year: | 2015 |
| Subject Terms: | /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM013909A; name=EMC MM-01-39-09-A; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES016402; name=EMC NIHES-01-64-02; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: | Obesity is highly heritable. Genetic variants showing robust associationswith obesity traits have been identified through genome wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. Totally, 32 body mass index (BMI)- and 14 waist-hip ratio (WHR)-associated single nucleotide polymorphismswere genotyped, and genetic risk scores (GRS) were calculated in 18 cohorts of European ancestry (n = 68 317). Diet score was calculated based on self-reported intakes of whole grains, fish, fruits, vegetables, nuts/seeds (favorable) and red/processed meats, sweets, sugar-sweetened beverages and fried potatoes (unfavorable). Multivariable adjusted, linear regression within each cohort followed by inverse variance-weighted, fixed-effects meta-analysis was used to characterize: (a) associations of each GRS with BMI and BMI-adjustedWHR and (b) diet score modification of genetic associations with BMI and BMI-adjusted WHR. Nominally significant interactions (P = 0.006-0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci (GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci (LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjustedWHR or BMI outcomes. Although the magnitudes of these select interactions were small, our data indicated that associations between genetic predisposition and obesity traits were stronger with a healthier diet. Our findings generate interesting hypotheses; however, experimental and functional studies are needed to determine their clinical relevance. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| ISSN: | 0964-6906; 1460-2083 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/25994509; info:eu-repo/semantics/altIdentifier/pissn/0964-6906; info:eu-repo/semantics/altIdentifier/eissn/1460-2083 |
| DOI: | 10.1093/hmg/ddv186 |
| Availability: | https://pure.eur.nl/en/publications/c5673bea-30a0-434a-b020-fecd3c8a14fe; https://doi.org/10.1093/hmg/ddv186; https://pure.eur.nl/ws/files/47644628/REPUB_85763-OA.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.BF2BDD04 |
| Database: | BASE |