| Title: |
24-h severe energy restriction impairs postprandial glycaemic control in young, lean males |
| Authors: |
Clayton, DJ; Biddle, J; Maher, T; Funnell, MP; Sargeant, JA; King, JA; Hulston, CJ; Stensel, DJ; James, LJ |
| Publisher Information: |
Cambridge University Press |
| Publication Year: |
2018 |
| Collection: |
Nottingham Trent University's Institutional Repository (IRep) |
| Description: |
Intermittent energy restriction (IER) involves short periods of severe energy restriction interspersed with periods of adequate energy intake, and can induce weight loss. Insulin sensitivity is impaired by short-term, complete energy restriction, but the effects of IER are not well known. In randomised order, fourteen lean men (age: 25 (sd 4) years; BMI: 24 (sd 2) kg/m2; body fat: 17 (4) %) consumed 24-h diets providing 100 % (10 441 (sd 812) kJ; energy balance (EB)) or 25 % (2622 (sd 204) kJ; energy restriction (ER)) of estimated energy requirements, followed by an oral glucose tolerance test (OGTT; 75 g of glucose drink) after fasting overnight. Plasma/serum glucose, insulin, NEFA, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and fibroblast growth factor 21 (FGF21) were assessed before and after (0 h) each 24-h dietary intervention, and throughout the 2-h OGTT. Homoeostatic model assessment of insulin resistance (HOMA2-IR) assessed the fasted response and incremental AUC (iAUC) or total AUC (tAUC) were calculated during the OGTT. At 0 h, HOMA2-IR was 23 % lower after ER compared with EB (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0007-1145 |
| Relation: |
https://irep.ntu.ac.uk/id/eprint/35118/1/12681_Clayton.pdf; CLAYTON, D.J., BIDDLE, J., MAHER, T., FUNNELL, M.P., SARGEANT, J.A., KING, J.A., HULSTON, C.J., STENSEL, D.J. and JAMES, L.J., 2018. 24-h severe energy restriction impairs postprandial glycaemic control in young, lean males. British Journal of Nutrition, 120 (10), pp. 1107-1116. ISSN 0007-1145 |
| DOI: |
10.1017/s0007114518002568 |
| Availability: |
https://irep.ntu.ac.uk/id/eprint/35118/; https://irep.ntu.ac.uk/id/eprint/35118/1/12681_Clayton.pdf; https://doi.org/10.1017/s0007114518002568 |
| Accession Number: |
edsbas.BFCB1F65 |
| Database: |
BASE |