| Title: |
Risk factors of dementia in a cohort of individuals with mild cognitive impairment in the Italian Interceptor project |
| Authors: |
Carrarini, Claudia; Caraglia, Naike; Quaranta, Davide; Vecchio, Fabrizio; Miraglia, Francesca; Giuffrè, Guido Maria; Pappalettera, Chiara; Cacciotti, Alessia; Nucci, Lorenzo; Vanacore, Nicola; Redolfi, Alberto; Perani, Daniela; Spadin, Patrizia; Tagliavini, Fabrizio; Cotelli, Maria; Cappa, Stefano; Marra, Camillo; Rossini, Paolo M. |
| Source: |
European Journal of Neurology ; volume 32, issue 2 ; ISSN 1351-5101 1468-1331 |
| Publisher Information: |
Wiley |
| Publication Year: |
2025 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background The Italian Interceptor project is aimed at identifying a prodromal dementia phase and developing a nationwide organizational model. This study compares the sociodemographic and neuropsychological characteristics of mild cognitive impairment non‐converters (MCI‐NC) and MCI‐converters (MCI‐C) to dementia, including Alzheimer's disease (AD), enrolled during the Interceptor project. Methods Sociodemographic, clinical, and neuropsychological data of MCI individuals were collected at baseline (December 2018 to October 2020) and every six‐month follow‐up visit for 3 years. Logistic regression and Random Forest classifier were used to describe the study population. Results From 356 participants, 104 were MCI‐C, whereas 252 were MCI‐NC. Compared to MCI‐NC, MCI‐C were predominantly female ( p = 0.020), older ( p < 0.001), and more cognitively impaired ( p < 0.001). Higher physical activity was protective for progression ( p < 0.001), but no difference was observed for smoking exposure ( p = 0.312) between the two groups. Similar results were found for AD individuals compared to MCI‐C/non‐AD. The ROC curve based on a Random Forest classifier distinguishing MCI‐C from MCI‐NC showed an area under the curve (AUC) of 0.7347. Conclusions Our findings confirm previous evidence in literature and may increase the insight on dementia pathology and help in defining intervention strategies to prevent or slow down disease progression. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/ene.16591 |
| Availability: |
https://doi.org/10.1111/ene.16591; https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.16591 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.BFD0B3B8 |
| Database: |
BASE |