| Title: |
Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus |
| Authors: |
Chan, Chee Eng; Ng, Tze Jian; Ahmad, Mohd Kamil; Mohamad Nor, Fariz Safhan |
| Source: |
Case Reports in Nephrology and Dialysis ; volume 12, issue 3, page 201-206 ; ISSN 2296-9705 |
| Publisher Information: |
S. Karger AG |
| Publication Year: |
2022 |
| Description: |
Renal involvement in systemic lupus erythematosus is usually exhibited as lupus nephritis, which is a form of immune complex-mediated glomerulonephritis and one of the most severe organ manifestations of systemic lupus erythematosus. The pathogenesis involved glomerular immune complex deposition, which leads to glomerular inflammation and typically shows a “full-house” pattern on immunofluorescence microscopy. Other forms of glomerulonephritis are rarely observed in patients with systemic lupus erythematosus. Pauci-immune crescentic glomerulonephritis is the pattern of injury most commonly observed in patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. The characteristic histological feature of pauci-immune crescentic glomerulonephritis is focal necrotizing and crescentic glomerulonephritis with little or no glomerular staining for immunoglobulin by immunofluorescence microscopy. We report a rare case of antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1159/000527248 |
| Availability: |
https://doi.org/10.1159/000527248; https://www.karger.com/Article/Pdf/527248 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.BFE61A5F |
| Database: |
BASE |