| Title: |
Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity |
| Authors: |
Lowe, William L.; Scholtens, Denise M.; Lowe, Lynn P.; Kuang, Alan; Nodzenski, Michael; Talbot, Octavious; Catalano, Patrick M.; Linder, Barbara; Brickman, Wendy J.; Clayton, Peter; Deerochanawong, Chaicharn; Hamilton, Jill; Josefson, Jami L.; Lashley, Michele; Lawrence, Jean M.; Lebenthal, Yael; Ma, Ronald; Maresh, Michael; Mccance, David; Tam, Wing Hung; Sacks, David A.; Dyer, Alan R.; Metzger, Boyd E. |
| Source: |
Lowe, W L, Scholtens, D M, Lowe, L P, Kuang, A, Nodzenski, M, Talbot, O, Catalano, P M, Linder, B, Brickman, W J, Clayton, P, Deerochanawong, C, Hamilton, J, Josefson, J L, Lashley, M, Lawrence, J M, Lebenthal, Y, Ma, R, Maresh, M, Mccance, D, Tam, W H, Sacks, D A, Dyer, A R & Metzger, B E 2018, 'Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity', JAMA, vol. 320, no. 10, pp. 1005-1016. https://doi.org/10.1001/jama.2018.11628 |
| Publication Year: |
2018 |
| Collection: |
The University of Manchester: Research Explorer - Publications |
| Subject Terms: |
Adiposity; Adolescent; Adult; Blood Glucose/analysis; Body Mass Index; Child; Diabetes Mellitus; Type 2/etiology; Diabetes; Gestational; Female; Follow-Up Studies; Humans; Male; Pediatric Obesity/etiology; Prediabetic State/etiology; Pregnancy; Waist Circumference |
| Description: |
Importance The sequelae of gestational diabetes (GD) by contemporary criteria that diagnose approximately twice as many women as previously used criteria are unclear.Objective To examine associations of GD with maternal glucose metabolism and childhood adiposity 10 to 14 years’ postpartum.Design, Setting, and Participants The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study established associations of glucose levels during pregnancy with perinatal outcomes and the follow-up study evaluated the long-term outcomes (4697 mothers and 4832 children; study visits occurred between February 13, 2013, and December 13, 2016).Exposures Gestational diabetes was defined post hoc using criteria from the International Association of Diabetes and Pregnancy Study Groups consisting of 1 or more of the following 75-g oral glucose tolerance test results (fasting plasma glucose ≥92 mg/dL; 1-hour plasma glucose level ≥180 mg/dL; 2-hour plasma glucose level ≥153 mg/dL).Main Outcomes and Measures Primary maternal outcome: a disorder of glucose metabolism (composite of type 2 diabetes or prediabetes). Primary outcome for children: being overweight or obese; secondary outcomes: obesity, body fat percentage, waist circumference, and sum of skinfolds (>85th percentile for latter 3 outcomes).Results The analytic cohort included 4697 mothers (mean [SD] age, 41.7 [5.7] years) and 4832 children (mean [SD] age, 11.4 [1.2] years; 51.0% male). The median duration of follow-up was 11.4 years. The criteria for GD were met by 14.3% (672/4697) of mothers overall and by 14.1% (683/4832) of mothers of participating children. Among mothers with GD, 52.2% (346/663) developed a disorder of glucose metabolism vs 20.1% (791/3946) of mothers without GD (odds ratio [OR], 3.44 [95% CI, 2.85 to 4.14]; risk difference [RD], 25.7% [95% CI, 21.7% to 29.7%]). Among children of mothers with GD, 39.5% (269/681) were overweight or obese and 19.1% (130/681) were obese vs 28.6% (1172/4094) and 9.9% (405/4094), respectively, for children of mothers without GD. ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: |
English |
| ISSN: |
0098-7484; 1538-3598 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/30208453; info:eu-repo/semantics/altIdentifier/wos/000444341400014; info:eu-repo/semantics/altIdentifier/pissn/0098-7484; info:eu-repo/semantics/altIdentifier/eissn/1538-3598 |
| DOI: |
10.1001/jama.2018.11628 |
| Availability: |
https://research.manchester.ac.uk/en/publications/dd6f1245-2f78-4d4d-9057-1a2fb61ecb57; https://doi.org/10.1001/jama.2018.11628; https://pure.manchester.ac.uk/ws/files/77773442/JAMA_revision_07_17_18_full.docx; https://www.scopus.com/pages/publications/85053242964 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C003712B |
| Database: |
BASE |