| Title: |
Bisphenol S Administered to Pregnant Ewes with Contrasted Metabolic Status Impaired the Ovarian Follicular Development of Fetuses and Lambs |
| Authors: |
Téteau, Ophélie; Jarrier-Gaillard, Peggy; Lasserre, Olivier; Papillier, Pascal; Desmarchais, Alice; Vignault, Claire; Maillard, Virginie; Binet, Aurélien; Lebachelier de la Riviere, Marie-Emilie; Picard-Hagen, Nicole; Elis, Sébastien |
| Contributors: |
Physiologie de la reproduction et des comportements Nouzilly (PRC); Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT); NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO); Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Centre Hospitalier Régional Universitaire de Tours (CHRU Bretonneau); Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER); ToxAlim (ToxAlim); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-École nationale vétérinaire de Toulouse (ENVT); Institut National Polytechnique (Toulouse) (Toulouse INP); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National Polytechnique (Toulouse) (Toulouse INP); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Ecole d'Ingénieurs de Purpan (INP - PURPAN); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); INRAE, the Centre Val-de-Loire Region (BEMOL project) and the Agence Nationale de la Recherche Française (ANR); ANR-18-CE34-0011,MAMBO,Impact du métabolisme sur les effets ovariens du bisphenol S(2018) |
| Source: |
19. International Congress on Animal Reproduction; https://hal.inrae.fr/hal-03715750; 19. International Congress on Animal Reproduction, Jun 2022, Bologna, Italy |
| Publisher Information: |
CCSD |
| Publication Year: |
2022 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio]; [SDV.BA]Life Sciences [q-bio]/Animal biology; [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]; [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology; [SDV.EE.SANT]Life Sciences [q-bio]/Ecology; environment/Health; [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism |
| Subject Geographic: |
Bologna; Italy |
| Description: |
International audience ; BACKGROUND-AIMThe size of the ovarian reserve, which is established by the number of primordial follicles, is defined before birth in ovine. The prenatal period is a critical window of sensitivity to environmental factors. Maternal metabolic status during gestation can influence fetal programming, and affect the ovarian reserve. Bisphenol A (BPA), a plasticizer used in food packaging, has deleterious effects on fetal folliculogenesis. It has been banned from the food industry and mainly replaced by bisphenol S (BPS). The objective of this study was to determine the effects of BPS 50 μg/kg/d in utero exposure on female fetuses and lambs from ewes with contrasted metabolic status on follicular population by ovarian histology.METHODSThis study was divided into two experiments performed on pregnant ewes exhibiting a contrasted metabolic status (lean versus well-fed). First, pregnant ewes were exposed to BPS by daily subcutaneous injection for 3 months, to analyze the ovarian development of the fetuses at 130 days of gestation. Second, pregnant ewes were exposed daily to BPS through food for 3 months and the lambs were then monitored up to 4 month-old (pre-puberty). Follicular population was characterized through follicle classification and counting on ovarian sections.RESULTSIn utero BPS exposure led to an increase in the number of pre-antral (p = 0.005) and antral follicles (p < 0.001) in fetuses and conversely to a decrease in 4 month-old lambs (p = 0.007). Besides, a significant interaction between maternal metabolic status and BPS exposure during gestation was reported for the number of primordial (p = 0.019), pre-antral (p = 0.003) and antral (p |
| Document Type: |
conference object; still image |
| Language: |
English |
| Availability: |
https://hal.inrae.fr/hal-03715750; https://hal.inrae.fr/hal-03715750v1/document; https://hal.inrae.fr/hal-03715750v1/file/ICAR2022_abstract-MEL.pdf |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.C015F911 |
| Database: |
BASE |