Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry
| Title: | Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry |
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| Authors: | Bucci, T; Shantsila, A; Romiti, GF; Teo, WS; Park, HW; Shimizu, W; Mei, DA; Tse, HF; Proietti, M; Chao, TF; Lip, GYH; David, CWS; Yodogawa, K; Tsutsui, H; Mukai, Y; Tomita, H; Horiuchi, D; Hagii, J; Aonuma, K; Okumura, Y; Goya, M; Hirao, K; Ajioka, M; Hagiwara, N; Suzuki, A; Yamane, T; Ikeda, T; Yuzawa, H; Satomi, K; Yazaki, Y; Fukuda, K; Kobayashi, Y; Morita, N; Murohara, T; Watanabe, E; Harada, M; Sakagami, S; Saeki, T; Kusano, K; Miyamoto, K; Miyazaki, S; Tada, H; Inoue, K; Tanaka, N; Koretsune, Y; Abe, H; Kihara, Y; Nakano, Y; Shimizu, A; Yoshiga, Y; Sakamoto, T; Okumur, K; Takahashi, N; Shinohara, T; Soejima, K; Takagi, M; Kawamura, M; Munetsugu, Y; Kim, SH; Shim, JM; Uhm, JS; Im, SI; Par, HS; Kim, JH; On, YK; Oh, IY; Shin, SY; Ko, JS; Park, JB; Won, KCK; Lim, TW; Foo, D; Chen, SA; Lin, YJ; Chung, FP; Hu, YF; Chang, SL; Tuan, TC; Liao, JN; Li, CH; Huang, JL; Hsieh, YC; Wu, TJ; Liao, YC; Hsiao, HC; Yeh, TC; Lin, WS; Lin, WY; Kuo, JY; Hong, CL; Wu, YJ; Li, YS; Tsai, JP; Sung, KT; Chang, SH |
| Publisher Information: | Springer Science and Business Media LLC |
| Publication Year: | 2023 |
| Collection: | The University of Liverpool Repository |
| Description: | We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia–Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 ± 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 ± 11 vs 67 ± 12 years, p < 0.001) and dyslipidemia (36.7% vs 41.7%, p = 0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p < 0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p = 0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38–0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22–0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://livrepository.liverpool.ac.uk/3176488/1/Bucci_et_al-2023-Scientific_Reports.pdf; Collapse authors list. Bucci, T orcid:0000-0003-2895-6234 , Shantsila, A orcid:0000-0002-0594-8576 , Romiti, GF, Teo, WS, Park, HW, Shimizu, W, Mei, DA, Tse, HF, Proietti, M orcid:0000-0003-1452-2478 , Chao, TF et al (show 85 more authors) , Lip, GYH orcid:0000-0002-7566-1626 , David, CWS, Yodogawa, K, Tsutsui, H, Mukai, Y, Tomita, H, Horiuchi, D, Hagii, J, Aonuma, K, Okumura, Y, Goya, M, Hirao, K, Ajioka, M, Hagiwara, N, Suzuki, A, Yamane, T, Ikeda, T, Yuzawa, H, Satomi, K, Yazaki, Y, Fukuda, K, Kobayashi, Y, Morita, N, Murohara, T, Watanabe, E, Harada, M, Sakagami, S, Saeki, T, Kusano, K, Miyamoto, K, Miyazaki, S, Tada, H, Inoue, K, Tanaka, N, Koretsune, Y, Abe, H, Kihara, Y, Nakano, Y, Shimizu, A, Yoshiga, Y, Sakamoto, T, Okumur, K, Takahashi, N, Shinohara, T, Soejima, K, Takagi, M, Kawamura, M, Munetsugu, Y, Kim, SH, Shim, JM, Uhm, JS, Im, SI, Par, HS, Kim, JH, On, YK, Oh, IY, Shin, SY, Ko, JS, Park, JB, Won, KCK, Lim, TW, Foo, D, Chen, SA, Lin, YJ, Chung, FP, Hu, YF, Chang, SL, Tuan, TC, Liao, JN, Li, CH, Huang, JL, Hsieh, YC, Wu, TJ, Liao, YC, Hsiao, HC, Yeh, TC, Lin, WS, Lin, WY, Kuo, JY, Hong, CL, Wu, YJ, Li, YS, Tsai, JP, Sung, KT and Chang, SH (2023) Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry Scientific Reports, 13 (1). 18375-. ISSN 2045-2322, 2045-2322 |
| DOI: | 10.1038/s41598-023-45345-3 |
| Availability: | https://livrepository.liverpool.ac.uk/3176488/; https://doi.org/10.1038/s41598-023-45345-3 |
| Accession Number: | edsbas.C0A44AF4 |
| Database: | BASE |