| Title: |
Are young people with Turner syndrome who have undergone treatment with growth and sex hormones at higher risk of metabolic syndrome and its complications? / |
| Authors: |
Krzyścin, Mariola; Sowińska-Przepiera, Elżbieta; Gruca-Stryjak, Karolina; Soszka-Przepiera, Ewelina; Syrenicz, Igor; Przepiera, Adam; Bumbulienė, Žana; Syrenicz, Anhelli |
| Source: |
Biomedicines., Basel : MDPI, 2024, vol. 12, iss. 5, art. no. 1034, p. [1-11]. ; eISSN 2227-9059 |
| Publication Year: |
2024 |
| Collection: |
Vilnius University Virtual Library (VU VL) / Vilniaus universitetas virtuali biblioteka |
| Subject Terms: |
body fat; hormone replacement therapy; metabolic syndrome; monosomy; mosaic karyotype; recombinant human growth hormone; Turner syndrome; visceral fat |
| Description: |
Introduction: Metabolic syndrome (MetS), characterized by visceral obesity, glucose abnormalities, hypertension and dyslipidemia, poses a significant risk of diabetes and cardiovascular disease. Turner syndrome (TS), resulting from X chromosome abnormalities, carries health complications. Despite growing evidence of an increased risk of MetS in women with TS, its prevalence and risk factors remain under investigation. These considerations are further complicated by the varying timing and dosages of treatment with growth hormone and sex hormones. Methods: We conducted a cross-sectional study comparing 44 individuals with TS with 52 age-matched control subjects. Growth hormone treatment in the study group was administered for varying lengths of time, depending on clinical response. We collected anthropometric, metabolic, endocrine and body composition data. Statistical analyses included logistic regression. Results: Baseline characteristics, including age, BMI and height, were comparable between the TS and control groups. Hormonally, individuals with TS showed lower levels of testosterone, DHEA-S, and cortisol, as well as elevated FSH. Lipid profiles indicated an atherogenic profile, and the body composition analysis showed increased visceral adipose tissue in those with TS. Other metabolic abnormalities were common in individuals with TS too, including hypertension and impaired fasting glucose levels. The risk of MetS components was assessed in subgroups according to karyotypes: monosomy 45X0 vs. other mosaic karyotypes. Logistic regression analysis showed a significant association between increased visceral adipose tissue in subjects with TS. Those with metabolic complications tended to have less muscle strength compared to those without these complications in both the study and control groups. Conclusions: This study highlights the unique metabolic and cardiovascular risk profile of individuals with TS, characterized by atherogenic lipids, higher levels of visceral adipose tissue and increased metabolic ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://epublications.vu.lt/object/elaba:206499641/206499641.pdf; https://repository.vu.lt/VU:ELABAPDB206499641&prefLang=en_US |
| Availability: |
https://repository.vu.lt/VU:ELABAPDB206499641&prefLang=en_US |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C0AFD165 |
| Database: |
BASE |