| Title: |
Association of Lipoprotein-Associated Phospholipase A 2 Mass and Activity With Calcified Coronary Plaque in Young Adults ; The CARDIA Study |
| Authors: |
Iribarren, Carlos; Gross, Myron D.; Darbinian, Jeanne A.; Jacobs, David R.; Sidney, Stephen; Loria, Catherine M. |
| Source: |
Arteriosclerosis, Thrombosis, and Vascular Biology ; volume 25, issue 1, page 216-221 ; ISSN 1079-5642 1524-4636 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2005 |
| Description: |
Objective— To examine the association of lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) mass and activity with calcified coronary plaque in young adults. Methods and Results— Nested case-control study among CARDIA participants at the year 15 examination (2000 to 2001, 33 to 45 years old). Cases (n=266) were those with and controls (n=266) those without evidence of calcified coronary plaque by computed tomography matched 1:1 on sex and race. Lp-PLA 2 mass and activity were significantly higher in cases (296±101 ng/mL and 36.4±12.3 nmol/mL per minute) than in controls (267±80 ng/mL and 32.9±11.8 nmol/mL per minute). In age-adjusted conditional logistic regression, the odds ratio (OR) of calcified coronary plaque per 1 standard deviation (SD) increment was 1.40 (95% CI, 1.17 to 1.67) and 1.39 (95% CI, 1.14 to 1.70) for Lp-PLA 2 mass and activity, respectively. After adjusting for multiple covariates including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and C-reactive protein, a statistically significant association remained for Lp-PLA 2 mass (OR, 1.28; 95% CI, 1.03 to 1.60) but not for activity (OR, 1.09; 95% CI, 0.84 to 1.42). No evidence was found for interaction between Lp-PLA 2 mass or activity with LDL-C as predictors of calcified coronary plaque. Conclusion— An independent association of Lp-PLA 2 mass with calcified coronary plaque existed in young adults. Therefore, Lp-PLA 2 mass may be a useful marker of subclinical cardiovascular risk. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/01.atv.0000148322.89911.44 |
| DOI: |
10.1161/01.ATV.0000148322.89911.44 |
| Availability: |
https://doi.org/10.1161/01.atv.0000148322.89911.44; https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000148322.89911.44 |
| Accession Number: |
edsbas.C0E11373 |
| Database: |
BASE |