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Clinical and genetic characteristics of late-onset Huntington's disease

Title:	Clinical and genetic characteristics of late-onset Huntington's disease
Authors:	Oosterloo M; Bijlsma EK; van Kuijk SM; Minkels F; de Die-Smulders C; Bachoud-Lévi AC; Bentivoglio AR; Biunno I; Bonelli RM; Bronzova J; Burgunder JM; Dunnett SB; Ferreira JJ; Frich J; Giuliano J; Handley OJ; Heiberg A; Illarioshkin S; Illmann T; Klempir J; Landwehrmeyer GB; Levey J; McLean T; Nielsen JE; Koivisto SP; Päivärinta M; Pålhagen S; Quarrell O; Ramos-Arroyo M; Roos RAC; Saft C; Sebastián AR; Tabrizi SJ; Vandenberghe W; Verellen-Dumoulin C; Uhrova T; Wahlström J; Zaremba J; Formerly Rödig VB; Barth K; Garde MB; Becanovic K; Bernard T; Betz S; Bos R; Come A; Guedes LC; Callaghan J; Capodarca S; Charpentier S; Vieira da Silva W; Di Renzo M; Ecker D; Finisterra AM; Fullam R; Genoves C; Gilling M; Horta A; Hvalstedt C; Held C; Hussain H; Koppers K; Lamanna C; Laurà M; Descals AM; Martinez-Horta S; Mestre T; Minster S; Monza D; Münkel K; Mütze L; Oehmen M; Padieu H; Paterski L; Peppa N; Rindal B; Rogers D; Røren Formerly Heinonen N; Salgueiro A; Šašinková P; Seliverstov Y; Taylor C; Timewell E; Townhill J; Cubillo PT; van Walsem MR; Witjes-Ané MN; Witkowski G; Wright A; Yudina E; Zielonka D; Zielonka E; Zinzi P; Hecht K; Herranhof B; Holl Formerly Hödl A; Kapfhammer HP; Koppitz M; Lilek S; Magnet M; Müller N; Otti D; Painold A; Reisinger K; Scheibl M; Schöggl H; Ullah J; Braunwarth EM; Brugger F; Buratti L; Hametner EM; Hepperger C; Holas C; Hotter A; Hussl A; Larcher B; Mahlknecht P; Müller C; Pinter B; Poewe W; Reiter EM; Seppi K; Sprenger F; Wenning G; Ladurner G; Sinadinosa D; Staffen W; Walleczek AM; Linder C; Pirker W; Liessens D; Calmeyn G; Somers N; Delvaux I; Boogaerts A; Flamez A; de Raedt S; Alaerts N; Slama H; Supiot F; Constant E; Gillardin AF; Léonard MC; van de Wyngaerde F; Dupuis M; Minet C; Ribaï P; Van Paemel D; van Reijen D; Weckx P; Kaiserova M; Šenkárová Z; Bezdíček O; Klempíř J; Klempířová O; Majerová-Ibarburu V; Nikolai T; Roth J; Stárková I; Madsen LH; Møller AT; Hjermind L; Jacobsen O; Larsen IU; Lindquist S; Nielsen J; Regeur L; Roos P; Stockholm J; Vangsted-Hansen C; Vinther-Jensen T; Lolk A; Lundsgaard M; Wermuth L; Andersson C; Nyberg C; Sundblom J; Peippo M; Sipponen M; Bruun A; Hartikainen P; Mäkipää S; Ollokainen M; Åman J; Kärppä M; Ignatius J; Jääskeläinen O; Kajula O; Moilanen J; Mustonen A; Santala M; Eklund P; Hiivola H; Hyppönen H; Martikainen K; Ojala M; Tähkäpää S; Tuuha K; Allain P; Bonneau D; Bost M; Gohier B; Guérid MA; Olivier A; Prouzet J; Prundean A; Scherer-Gagou C; Verny C; Babiloni B; Bled D; Debruxelles S; Duché C; Fraisse S; Goizet C; Jameau L; Lafoucrière D; Spampinato U; Couttier J; Debilly B; Delaigue C; Derost P; Durif F; Germain V; Legendre P; Loiseau S; Marques A; Ulla M; Vidal T; Badei F; Boissé MF; Boudali L; Cleret de Langavant L; Lemoine L; Morgado G; Youssov K; Annic A; Barthélémy R; De Bruycker C; Cabaret M; Carette AS; Carrière N; Decorte E; Defebvre L; Delliaux M; Delval A; Depelchin A; Destee A; Dewulf-Pasz N; Dondaine T; Dugauquier F; Dujardin K; Hopes L; Krystkowiak P; Lemaire MH; Manouvrier S; Mutez E; Peter M; Plomhause L; Sablonnière B; Simonin C; Tard C; Thibault-Tanchou S; Vuillaume I; Bellonet M; Blin S; Chen S; Masmoudi K; Morin G; Roussel M; Tir M; Schüler B; Wannepain S; Zouitina Y; Azulay JP; Delfini M; Eusebio A; Fluchere F; Guenam A; Mundler L; Nguyen K; Benaich S; Brice A; Boster S; Charles P; Durr A; Ewenczyk C; Francisque H; Jauffret C; Justo D; Kassar A; Klebe S; Lesne F; Milani P; Monin ML; Monnier T; Roze E; Tataru A; Tchikviladzé M; Bioux S; Bliaux E; Girard C; Guyant-Maréchal L; Hannequin D; Hannier V; Jourdain S; Maltête D; Pouliquen D; Anheim M; Barun N; Lagha-Boukbiza O; Longato N; Marcel C; Phillipps C; Rudolf G; Steinmetz G; Tranchant C; Wagner C; Zimmermann MA; Blondeau L; Calvas F; Cheriet S; Delabaere H; Demonet JF; Marquine L; Pariente J; Pierre M; Pomies E; Rolland S; Souyris C; Kosinski CM; Milkereit E; Probst D; Reetz K; Sass C; Schiefer J; Schlangen C; Werner CJ; Beuth M; Gelderblom H; Priller J; Prüß H; Spruth E; Thiel S; Andrich J; Ellrichmann G; Herrmann L; Hoffmann R; Kaminski B; Kraus P; Stamm C; Ganos C; Stubbe L; Tadic V; Tübing J; Lange H; Bosredon C; Hunger U; Löhle M; Maass A; Ossig C; Schmidt S; Storch A; Wolz A; Wolz M; Kohl Z; Kozay C; Winkler J; Bergmann U; Böringer R; Capetian P; Kammel G; Lambeck J; Mächtel M; Meier S; Rijntjes M; Zucker B; Boelmans K; Goerendt I; Heinicke W; Hidding U; Lewerenz J; Münchau A; Orth M; Schmalfeld J; Zittel S; Diercks G; Dressler D; Francis F; Gayde-Stephan S; Gorzolla H; Kramer B; Minschke R; Schrader C; Tacik P; Ribbat M; Longinus B; Möller C; Bürk K; Lüsebrink A; Mühlau M; Peinemann A; Städtler M; Weindl A; Winkelmann J; Ziegler C; Bechtel N; Beckmann H; Bohlen S; Göpfert N; Hölzner E; Reilmann R; Rohm S; Rumpf S; Schepers S; Weber N; Bachmeier M; Dose M; Hofstetter N; Marquard R; Mühlbäck A; Buck A; Connemann J; Geitner C; Kesse A; Landwehrmeyer B; Lezius F; Nepper S; Niess A; Schneider A; Schwenk D; Süssmuth S; Trautmann S; Vogel M; Weydt P; Musacchio T; Leypold C; Nöth K; Cormio C; Difruscolo O; Franco G; Nuzzi A; Sciruicchio V; Serpino C; de Tommaso M; Calandra-Buonaura G; Capellari S; Cortelli P; Gallassi R; Poda R; Scaglione C; Agosti C; Barlati S; Compostella S; Marchina E; Padovani A; Figorilli M; Marrosu F; Muroni A; Piras V; Vacca M; Bertini E; Bartoli C; Fortunato F; Ghelli E; Ginestroni A; Mechi C; Paganini M; Piacentini S; Pradella S; Romoli AM; Sorbi S; Abbruzzese G; Bandettini di Poggio M; Ferrandes G; Mandich P; Marchese R; Di Maria E; Tamburini T; Albanese A; Castagliuolo S; Castaldo A; Di Donato S; Di Bella D; Gellera C; Genitrini S; Mariotti C; Nanetti L; Panzeri M; Paridi D; Soliveri P; Spagnolo F; Taroni F; Tomasello C; De Michele G; Di Maio L; Rinaldi C; Massarelli M; Peluso S; Roca A; Russo CV; Salvatore E; Sorrentino P; Tucci T; Cannella M; Codella V; De Gregorio F; De Nicola A; Elifani F; Esposito C; Martino T; Mazzante I; Petrollini M; Simonelli M; Vezza M; Squitieri F; D'Alessio B; Lovo F; Bove F; Catalli C; Di Giacopo R; Fasano A; Frontali M; Guidubaldi A; Ialongo T; Jacopini G; Loria G; Modoni A; Petracca M; Piano C; Chiara P; Quaranta D; Romano S; Soleti F; Solito M; Spadaro M; Torlizzi F; Coarelli G; Ferraldeschi M; Ristori G; van Hout MSE; van Vugt JPP; Marit de Weert A; Verhoeven M; Dekker M; Klooster J; Leenders N; van Oostrom J; Kremer B; Baake V; van den Bogaard SJA; Dumas EM; T Hart EP; Hogenboom M; Jacobs M; Jurgens C; Kampstra A; Schoonderbeek A; Duits A; Waber M; Verstappen C; Blinkenberg EØ; Hauge E; Tyvoll H; Aaserud O; Aanonsen NO; Bjørgo K; Borgerød N; Dramstad E; Fannemel M; Frich JC; Gørvell PF; Haggag K; Johannessen CH; Retterstøl L; Røsby O; Rummel J; Sikiric A; Stokke B; van Walsem M; Wehus R; Arntsen V; Bjørnevoll I; Sando SB; Haug MG; Størseth HH; Østern R; Paulsen J; Dziadkiewicz A; Konkel A; Narożańska E; Nowak M; Robowski P; Sitek E; Slawek J; Soltan W; Szinwelski M; Arkuszewski M; Błaszczyk M; Boczarska-Jedynak M; Ciach-Wysocka E; Gorzkowska A; Jasińska-Myga B; Kaczmarczyk A; Kłodowska-Duda G; Opala G; Rudzińska M; Stompel D; Banaszkiewicz K; Boćwińska D; Bojakowska-Jaremek K; Dec M; Grabska N; Krawczyk M; Kubowicz E; Malec-Litwinowicz M; Stenwak A; Szczudlik A; Szczygieł E; Wójcik M; Wasielewska A; Anna Bryl JA; Ciesielska A; Klimberg A; Marcinkowski J; Samara H; Sempołowicz J; Wiśniewski B; Gogol Formerly Kalbarczyk A; Janik P; Jamrozik Z; Kaminska A; Kwiecinski H; Antczak J; Jachinska K; Krysa W; Rakowicz M; Rola R; Ryglewicz D; Sienkiewicz-Jarosz H; Stępniak I; Sułek A; Zdzienicka E; Ziora-Jakutowicz K; Januário C; Júlio F; Almeida M; Calado A; Dias M; Morgado J; Semedo C; Coelho M; Magalhães A; Mendes T; Neutel D; Rodrigues F; Valadas A; Costa C; Cardoso H; Santos M; Cação G; Cavaco S; Damásio J; Fernandes J; Gonçalves A; Loureiro R; Moreira I; Magalhães M; Salgado P; Andrade C; Costa A; Garrett C; Gago M; Guimarães J; Massano J; Meireles J; Monteiro A; Khasanova D; Zalyalova Z; Klyushnikov S; Sidorova O; Smirnov O; Antonova V; Kopishinskaya S; Korotysh M; Magzhanov R; Saifullina E; Kurbatov S; Solis P; Herrera CD; Moreno PG; Bas J; Busquets N; Calopa M; Classen SJ; Dedichá NR; Buongiorno MT; María ACS; Muñoz E; Santacruz P; Barbera MA; Pardo SA; Guia DB; Calzado N; Hernanz LC; Tartari Díaz-Zorita JP; Catena JL; Ferrer PQ; Carruesco GT; Robert MF; Viladrich CM; Roca E; Ruiz Idiago JM; Riballo AV; Campolongo A; Fernandez de Bobadilla R; Bojarsky JK; Pagonabarraga J; Perez JP; Ribosa R; Villa C; Acera Gil MA; Corrales KB; Gomez Esteban JC; González A; Merino BT; Cubo E; Polo CG; Mariscal N; Sánchez J; Romero SG; Arbelo JM; Malo de Molina R; Martín I; Periañez JM; Udaeta B; Alonso-Frech F; Loarte MDV; Barrero F; Morales B; Frades B; Villanueva MÁ; Zea Sevilla MA; Fenollar MDM; García-Ramos García R; Villanueva C; Bascuñana M; Ventura MF; Caldentey JG; Ribas GG; García de Yébenes J; López-Sendón Moreno JL; Barral VM; Feliz C; García Ruíz PJ; García A; López RG; Bárcenas AH; Martínez-Descals A; Pueyo AM; Martin VP; Martínez NR; Montojo T; Sainz Artiga MJ; Sánchez V; Alarcón MD; Almagro CA; Diéguez E; Fortuna L; Legaz A; Manzanares S; Muñoz JM; Antequera Torres MM; Perea FN; Vivancos L; González S; Guisasola LM; Prieto MP; Ribacoba R; Salvador C; Lozano PS; Ramirez IL; Benito DM; Arques PN; Lopera MR; Pastor BV; Gaston I; Garcia-Amigot F; Martinez-Jaurrieta MD; Ramos-Arroyo MA; Adarmes A; Bernal-Escudero M; Carrillo F; Jesús S; Mir P; Vargas-González L; Hermoso FD; García Moreno JM; Jaramillo JA; Lucena CM; Pacheco Cortegana EM; Peña JC; Redondo L; Sánchez VS; Fernandez CM; Romero Lemos MD; Mata MP; Casado RV; Bosca M; Burguera JA; Brugada FC; Millán Salvador JM; Vilaplana CP; Solís P; Figuerola BJ; Palanca PM; Diago EB; López Del Val J; Martinez LM; López E; Høsterey-Ugander U; Fredlund G; Constantinescu R; Lewin K; Neleborn-Lingefjärd L; Berglund M; Berglund P; Linnsand P; Petersén Å; Reimer J; Widner H; Esmaeilzadeh M; Tedroff J; Winnberg E; Benaminov S; Björnsson E; Merrick D; Paucar M; Svenningsson P; Wallden T; Loutfi G; Olofsson C; Stattin EL; Westman L; Wikström B; Ekwall C; Göller ML; Johansson A; Niemelä V; Nyholm D; Wiklund L; Koehli J; Stebler Y; Kaelin A; Romero I; Schüpbach M; Zaugg SW; Esposito F; Good JM; Paus K; Vingerhoets F; Wider C; Jung HH; Petersen JA; Ligon-Auer M; Mihaylova V; Downie L; Jack R; Matheson K; Miedzybrodzka Z; Rae D; Simpson SA; Summers F; Ure A; Vaughan V; Harrower T; Vernon N; Akhtar S; Crooks J; Curtis A; de Souza Keylock J; Piedad J; Rickards H; Wright J; Haig-Brown D; Craven J; Pallett A; Simpson S; Weekes R; Coulthard E; Gethin L; Hayward B; Sieradzan K; Barker RA; O'Keefe D; Gerrtiz Nee Di Pietro A; Fisher K; Goodman A; Hill S; Mason S; Swain R; Guzman NV; Busse M; Butcher C; Dunnett S; Clenaghan C; Hunt S; Jones L; Jones U; Khalil H; Owen M; Price K; Rosser A; Goudie D; Buchanan L; McFadyen P; Tonner A; Taylor AM; Edwards M; Ho C; McGill M; Porteous M; Pearson P; Irvine S; Brockie P; Foster J; Johns N; McKenzie S; Rothery J; Thomas G; Yates S; Neumann C; Patterson K; Thomson D; Deith C; Ireland J; Ritchie S; Brown P; Burrows L; Fletcher A; Harding A; Harrison K; Laver F; Silva M; Thomson A; Chu C; Evans C; Gallentree D; Hamer S; Kraus A; Markova I; Raman A; Rowett L; Andrew A; Frost J; Noad R; Cosgrove J; Gallantree D; Hobson E; Jamieson S; Longthorpe M; Musgrave H; Peacy C; Toscano J; Wild S; Yardumian P; Clayton C; Dipple H; Freire-Patino D; Hallam C; Middleton J; Alusi S; Davies R; Foy K; Gerrans E; Pate L; Anjum U; Coebergh J; Eddy C; Lahiri N; McEntagart M; Patton M; Peterson M; Rose S; Andrews T; Dougherty A; Golding C; Kavalier F; Laing H; Lashwood A; Robertson D; Ruddy D; Santhouse A; Whaite A; Gosling Nee Brown S; Bruno S; Chu E; Doherty K; Haider S; Hensman D; Lewis M; Novak M; Patel A; Robertson N; Rosser E; Tabrizi S; Taylor R; Warner T; Wild E; Ackermann O; Duport S; Scott A; Stoy N; Vaughn J; Arran N; Bek J; Craufurd D; Hare M; Howard L; Huson S; Johnson L; Jones M; Krishnamoorthy A; Murphy H; Oughton E; Partington-Jones L; Sollom A; Snowden J; Stopford C; Thompson J; Trender-Gerhard I; Verstraelen Formerly Ritchie N; Westmoreland L.
Contributors:	Oosterloo, M; Bijlsma, Ek; van Kuijk, Sm; Minkels, F; de Die-Smulders, C; Bachoud-Lévi, Ac; Bentivoglio, Ar; Biunno, I; Bonelli, Rm; Bronzova, J; Burgunder, Jm; Dunnett, Sb; Ferreira, Jj; Frich, J; Giuliano, J; Handley, Oj; Heiberg, A; Illarioshkin, S; Illmann, T; Klempir, J; Landwehrmeyer, Gb; Levey, J; Mclean, T; Nielsen, Je; Koivisto, Sp; Päivärinta, M; Pålhagen, S; Quarrell, O; Ramos-Arroyo, M; Roos, Rac; Saft, C; Sebastián, Ar; Tabrizi, Sj; Vandenberghe, W; Verellen-Dumoulin, C; Uhrova, T; Wahlström, J; Zaremba, J; Formerly Rödig, Vb; Barth, K; Garde, Mb; Becanovic, K; Bernard, T; Betz, S; Bos, R; Come, A; Guedes, Lc; Callaghan, J; Capodarca, S; Charpentier, S; Vieira da Silva, W; Di Renzo, M; Ecker, D; Finisterra, Am; Fullam, R; Genoves, C; Gilling, M; Horta, A; Hvalstedt, C; Held, C; Hussain, H; Koppers, K; Lamanna, C; Laurà, M; Descals, Am; Martinez-Horta, S; Mestre, T; Minster, S; Monza, D; Münkel, K; Mütze, L; Oehmen, M; Padieu, H; Paterski, L; Peppa, N; Rindal, B; Rogers, D; Røren Formerly Heinonen, N; Salgueiro, A; Šašinková, P; Seliverstov, Y; Taylor, C; Timewell, E; Townhill, J; Cubillo, Pt; van Walsem, Mr; Witjes-Ané, Mn; Witkowski, G; Wright, A; Yudina, E; Zielonka, D; Zielonka, E; Zinzi, P; Hecht, K; Herranhof, B; Holl Formerly Hödl, A; Kapfhammer, Hp
Publisher Information:	Elsevier Ltd
Publication Year:	2019
Collection:	Università degli Studi di Genova: CINECA IRIS
Subject Terms:	Age of onset; Huntington's disease; Late-onset Huntington's disease; Neurology; Geriatrics and Gerontology; Neurology (clinical)
Description:	Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/30528461; info:eu-repo/semantics/altIdentifier/wos/WOS:000468719900018; volume:61; firstpage:101; lastpage:105; numberofpages:5; journal:PARKINSONISM & RELATED DISORDERS; https://hdl.handle.net/11567/934639
DOI:	10.1016/j.parkreldis.2018.11.009
Availability:	https://hdl.handle.net/11567/934639; https://doi.org/10.1016/j.parkreldis.2018.11.009
Rights:	info:eu-repo/semantics/closedAccess
Accession Number:	edsbas.C14A583F
Database:	BASE