| Title: |
Agrimonia coreana Extract Exerts Its Therapeutic Effect through CRAC Channel Inhibition for Atopic Dermatitis Treatment |
| Authors: |
Jintae Kim; Ji Min Lee; Su Jin Park; Yu Ran Nam; Seong Woo Choi; Joo Hyun Nam; Hyun Jong Kim; Woo Kyung Kim |
| Source: |
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8894 (2024) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2024 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Atopic dermatitis; Agrimonia coreana; CRAC channel; T lymphocyte; Biology (General); QH301-705.5; Chemistry; QD1-999 |
| Description: |
Atopic dermatitis (AD) is a common allergic inflammatory skin condition marked by severe itching, skin lichenification, and chronic inflammation. AD results from a complex immune response, primarily driven by T lymphocytes and environmental triggers, leading to a disrupted epidermal barrier function. Traditional treatments, such as topical corticosteroids, have limitations due to long-term side effects, highlighting the need for safer alternatives. Here, we aimed to show that Agrimonia coreana extract (AC ext ) can be used in treating AD-related dermatologic symptoms. AC ext could inhibit CRAC (Calcium Release-Activated Calcium) channel activity, reducing Orai1/CRAC currents and decreasing intracellular calcium signaling. This inhibition was further confirmed by the reduced IL-2 levels and T cell proliferation upon AC ext treatment. In a mouse model of AD, AC ext significantly ameliorates symptoms, improves histological parameters, and enhances skin barrier function, demonstrating its potential for treating AD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/1422-0067/25/16/8894; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/5a128bca35f54647a51a11d07f2f065a |
| DOI: |
10.3390/ijms25168894 |
| Availability: |
https://doi.org/10.3390/ijms25168894; https://doaj.org/article/5a128bca35f54647a51a11d07f2f065a |
| Accession Number: |
edsbas.C16C65E6 |
| Database: |
BASE |