| Title: |
Embryonal precursors of Wilms tumor |
| Authors: |
Coorens, Tim H. H.; Treger, Taryn D.; Al-Saadi, Reem; Moore, Luiza; Tran, Maxine G. B.; Mitchell, Thomas J.; Tugnait, Suzanne; Thevanesan, Christine; Young, Matthew D.; Oliver, Thomas R. W.; Oostveen, Minou; Collord, Grace; Tarpey, Patrick S.; Cagan, Alex; Hooks, Yvette; Brougham, Mark; Reynolds, Ben C.; Barone, Giuseppe; Anderson, John; Jorgensen, Mette; Burke, G. A. Amos; Visser, Johannes; Nicholson, James C.; Smeulders, Naima; Mushtaq, Imran; Stewart, Grant D.; Campbell, Peter J.; Wedge, David C.; Martincorena, Iñigo; Rampling, Dyanne; Hook, Liz; Warren, Anne Y.; Coleman, Nicholas; Chowdhury, Tanzina; Sebire, Neil; Drost, Jarno; Saeb-Parsy, Kourosh; Stratton, Michael R.; Straathof, Karin; Pritchard-Jones, Kathy; Behjati, Sam |
| Contributors: |
Wellcome Trust; St. Baldrick's Foundation; Cancer Research UK; Royal College of Surgeons of England; Great Ormond Street Hospital Children’s Charity; The Little Princess Trust; National Institute of Health Research UK; KWF Dutch Cancer Society Bas Mulder Award; Oncode Institute |
| Source: |
Science ; volume 366, issue 6470, page 1247-1251 ; ISSN 0036-8075 1095-9203 |
| Publisher Information: |
American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2019 |
| Description: |
A childhood tumor—from the beginning Many adult cancers arise from clonal expansions of mutant cells in normal tissue. These premalignant expansions are defined by somatic mutations shared by the cancers. Whether pediatric cancers originate in a similar way is unknown. Coorens et al. studied Wilms tumor, a childhood kidney cancer. Phylogenetic analyses revealed large clones of mutant cells in histologically and functionally normal kidney tissue long before tumor development. Thus, like adult tumors, Wilms tumor appears to arise from a premalignant tissue bed. Science , this issue p. 1247 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1126/science.aax1323 |
| Availability: |
https://doi.org/10.1126/science.aax1323; https://syndication.highwire.org/content/doi/10.1126/science.aax1323; https://www.science.org/doi/pdf/10.1126/science.aax1323 |
| Accession Number: |
edsbas.C18886FF |
| Database: |
BASE |