| Title: |
Association of alcohol-induced loss of consciousness and overall alcohol consumption with risk for dementia |
| Authors: |
Kivimäki, M; Singh-Manoux, A; Batty, GD; Sabia, S; Sommerlad, A; Floud, S; Jokela, M; Vahtera, J; Beydoun, MA; Suominen, SB; Koskinen, A; Väänänen, A; Goldberg, M; Zins, M; Alfredsson, L; Westerholm, PJM; Knutsson, A; Nyberg, ST; Sipilä, PN; Lindbohm, JV; Pentti, J; Livingston, G; Ferrie, JE; Strandberg, T |
| Publisher Information: |
American Medical Association |
| Publication Year: |
2023 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Importance Evidence on alcohol consumption as a risk factor for dementia usually relates to overall consumption. The role of alcohol-induced loss of consciousness is uncertain. Objective To examine the risk of future dementia associated with overall alcohol consumption and alcohol-induced loss of consciousness in a population of current drinkers. Design, Setting, and Participants Seven cohort studies from the UK, France, Sweden, and Finland (IPD-Work consortium) including 131 415 participants were examined. At baseline (1986-2012), participants were aged 18 to 77 years, reported alcohol consumption, and were free of diagnosed dementia. Dementia was examined during a mean follow-up of 14.4 years (range, 12.3-30.1). Data analysis was conducted from November 17, 2019, to May 23, 2020. Exposures Self-reported overall consumption and loss of consciousness due to alcohol consumption were assessed at baseline. Two thresholds were used to define heavy overall consumption: greater than 14 units (U) (UK definition) and greater than 21 U (US definition) per week. Main Outcomes and Measures Dementia and alcohol-related disorders to 2016 were ascertained from linked electronic health records. Results Of the 131 415 participants (mean [SD] age, 43.0 [10.4] years; 80 344 [61.1%] women), 1081 individuals (0.8%) developed dementia. After adjustment for potential confounders, the hazard ratio (HR) was 1.16 (95% CI, 0.98-1.37) for consuming greater than 14 vs 1 to 14 U of alcohol per week and 1.22 (95% CI, 1.01-1.48) for greater than 21 vs 1 to 21 U/wk. Of the 96 591 participants with data on loss of consciousness, 10 004 individuals (10.4%) reported having lost consciousness due to alcohol consumption in the past 12 months. The association between loss of consciousness and dementia was observed in men (HR, 2.86; 95% CI, 1.77-4.63) and women (HR, 2.09; 95% CI, 1.34-3.25) during the first 10 years of follow-up (HR, 2.72; 95% CI, 1.78-4.15), after excluding the first 10 years of follow-up (HR, 1.86; 95% CI, 1.16-2.99), and for ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1001/jamanetworkopen.2020.16084 |
| DOI: |
10.1001/jamanetworkopen.2020.16084 |
| Availability: |
https://doi.org/10.1001/jamanetworkopen.2020.16084; https://ora.ox.ac.uk/objects/uuid:1739b010-1e02-439b-b832-e2ad9c700948 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.C194FA89 |
| Database: |
BASE |