| Title: |
Global patterns of utilization of noninvasive tests for the clinical management of metabolic dysfunction–associated steatotic liver disease |
| Authors: |
Allen, AM; Lazarus, JV; Alkhouri, N; Noureddin, M; Wong, VWS; Tsochatzis, EA; de Avila, L; Racila, A; Nader, F; Mark, HE; Henry, L; Stepanova, M; Castera, L; Younossi, ZM |
| Source: |
Hepatology Communications , 9 (5) , Article e0678. (2025) |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
2D-SWE; ELF; Fib-4; risk stratification; VCTE |
| Description: |
BACKGROUND: Noninvasive tests (NITs) are used to risk-stratify metabolic dysfunction–associated steatotic liver disease. The aim was to survey global patterns of real-world use of NITs. METHODS: A 38-item survey was designed by the Global NASH Council. Providers were asked about risks for advanced fibrosis, which NITs (cutoff values) they use to risk-stratify liver disease, monitor progression, and which professional guidelines they follow. RESULTS: A total of 321 participants from 43 countries completed the survey (54% hepatologists, 28% gastroenterologists, and 18% other). Of the respondents, 85% would risk-stratify patients with type 2 diabetes, obesity (82%), or abnormal liver enzymes (73%). Among NITs to rule out significant or advanced fibrosis, transient elastography (TE) and fibrosis-4 (FIB-4) were most used, followed by NAFLD Fibrosis Score, Enhanced Liver Fibrosis, and magnetic resonance elastography. The cutoffs for ruling out significant fibrosis varied considerably between practices and from guidelines, with only 50% using TE |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10209623/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10209623/1/Global%20patterns%20of%20utilization%20of%20noninvasive%20tests%20for%20the%20clinical%20management%20of%20metabolic%20dysfunction-associated%20steatoti.pdf; https://discovery.ucl.ac.uk/id/eprint/10209623/ |
| Rights: |
open |
| Accession Number: |
edsbas.C1AF16A0 |
| Database: |
BASE |